STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Coexpression
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[Homology]
Score
MCBB_1472Aromatic-amino-acid aminotransferase 1; Catalyzes the transamination of phenylalanine,tyrosine and tryptophan. Shows virtually no activity towards aspartic acid, alanine, valine or isoleucine. aromatic oxo acid + L-glutamate. Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Kinetic parameters: KM=0.55 mM for phenylalanine; KM=2.39 mM for tyrosine; KM=1.47 mM for tryptophan; KM=0.44 mM for 2-oxoglutarate; Temperature dependence: Optimum temperature is 95-100 degrees Celsius; aminotransferase family; sp|H3ZPL1|ARAT1_THELN;evalue=6e-092; PctID=43.04; score=338. (390 aa)    
Predicted Functional Partners:
leuB1
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity). 2-oxopentanoate + CO(2) + NADH. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit; leucine from 3-methyl-2-oxobutanoate: step 3/4. dehydrogenases family; sp|O27441|LEU3_METTH;evalue=2e-108; PctID=62.04; score=392.
  
 0.921
hdrA1
CoB-CoM heterodisulfide reductase 1 iron-sulfur subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
   
   0.791
hdrA3
CoB-CoM heterodisulfide reductase iron-sulfur subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
   
   0.791
lutB
Lactate utilization protein B; Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate. Rule:MF_02103}; sp|B9E9G9|LUTB_MACCJ;evalue=6e-042; PctID=34.17; score=171; {ECO:0000255|HAMAP-Rule:MF_02103}.
 
 
   0.690
hdrC1
CoB-CoM heterodisulfide reductase 1 iron-sulfur subunit C; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). N-(7-((2-sulfoethyl)dithio)heptanoyl)-O(3)-phospho-L- threonine + dihydromethanophenazine. Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 2 [4Fe-4S] clusters per subunit; heterodisulfide reduction; coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1. subunits; HdrA, HdrB and HdrC; sp|Q8PY84|HDRC_METMA;evalue=4e-013; PctID=37.78; score=74.7.
   
   0.619
hdrB1
CoB-CoM heterodisulfide reductase subunit B; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrB may have a function in energy transduction (By similarity). N-(7-((2-sulfoethyl)dithio)heptanoyl)-O(3)-phospho-L- threonine + dihydromethanophenazine. heterodisulfide reduction; coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1. subunits; HdrA, HdrB and HdrC. It forms a complex with the F420-non-reducing hydrogenase (Mvh), which provides the reducing equivalents to th [...]
   
   0.619
hdrB3
CoB-CoM heterodisulfide reductase subunit B; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrB may have a function in energy transduction. N-(7-((2-sulfoethyl)dithio)heptanoyl)-O(3)-phospho-L- threonine + dihydromethanophenazine. heterodisulfide reduction; coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1. subunits; HdrA, HdrB and HdrC. It forms a complex with the F420-non-reducing hydrogenase (Mvh), which provides the reducing equivalents to the heterodisulfid [...]
   
   0.619
hdrC3
CoB-CoM heterodisulfide reductase iron-sulfur subunit C; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrC may carry electrons from hydrogenase to HdrA. N-(7-((2-sulfoethyl)dithio)heptanoyl)-O(3)-phospho-L- threonine + dihydromethanophenazine. Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 2 [4Fe-4S] clusters per subunit; heterodisulfide reduction; coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1. subunits; HdrA, HdrB and HdrC. It forms a [...]
   
   0.619
yrdC
Putative isochorismatase family protein YrdC; sp|O07081|YRDC_BACSU;evalue=1e-019; PctID=31.32; score=96.3.
  
  
 0.541
MCBB_0697
Putative transporter MTH_841; sp|O26929|Y841_METTH;evalue=2e-049; PctID=34.94; score=196.
 
   
 0.454
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
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