STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MPG1Mannose-1-phosphate guanyltransferase; Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint (By similarity). diphosphate + GDP-mannose. biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1; sp|Q752H4|MPG1_ASHGO;evalue=2e-047; PctID=34.13; score=190. (381 aa)    
Predicted Functional Partners:
glmM-2
Putative phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. glucosamine 6-phosphate. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit; Rule:MF_01554}. Sequence=AAM06397.1; Type=Erroneous initiation; Evidence=; sp|Q8TLL2|GLMM_METAC;evalue=8e-050; PctID=30.16; score=198; {ECO:0000255|HAMAP-Rule:MF_01554}.
 
 0.997
MCBB_0186
Phosphoglucomutase/phosphomannomutase{03|}; Catalyzes the interconversion of glucose 1-phosphate and glucose 6-phosphate, and the interconversion of mannose 1-phosphate and mannose 6-phosphate. Also displays low activity with deoxyribose 1-phosphate and glucosamine 1-phosphate. 6-phosphate. phosphate. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Can also use Ni(2+), Mn(2+) and Zn(2+), to a lesser extent; Kinetic parameters: KM=3.0 mM for glucose 1-phosphate; KM=3.2 mM for mannose 1-phosphate; KM=3.5 mM for 2-deoxyribose 1-phosphate; Vmax=690 umol/min/mg enzyme with glucose 1-ph [...]
 
 0.994
glmM
Putative phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.
  
 0.947
gmd
GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose. rhamnose + H(2)O. Name=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence=; biosynthesis. family. GDP-mannose 4,6-dehydratase subfamily; sp|Q51366|GM4D_PSEAE;evalue=5e-016; PctID=34.15; score=85.9; {ECO:0000255|HAMAP-Rule:MF_00955}.
    
 0.920
eif2a
Translation initiation factor 2 subunit alpha; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.
   
 0.907
eif2g
Translation initiation factor 2 subunit gamma; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
   
 0.867
Gtpbp1
GTP-binding protein 1; Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity. HNRNPD, HNRNPR and SYNCRIP. Identified in a complex with HNRNPD, HNRNPL, HNRNPQ,HNRNPR, HNRNPU and AANAT mRNA, but does not bind mRNA by itself. superfamily. Classic translation factor GTPase family. GTPBP1 subfamily. domain; sp|D2XV59|GTPB1_RAT;evalue=1e-062; PctID=31.29; score=241.
   
 0.867
eif2b
Translation initiation factor 2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family.
  
 
 0.706
tarI
Putative ribitol-5-phosphate cytidylyltransferase; Provides activated ribitol phosphate for teichoic acid synthesis. CDP-ribitol. acid biosynthesis; sp|Q8RKI9|TARI_BACPZ;evalue=1e-075; PctID=56.22; score=282.
  
 
 0.667
agl12
Low-salt glycan biosynthesis protein Agl12; Lyase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at 'Asn-532' of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier. Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence=; Note=Binds 1 NAD(+) per subunit; present at 'Asn-532' of S-layer glycoprotein Csg. No effect on 'Asn-47' and 'A [...]
 
  
 0.615
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.