STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
moaBCatalyzes the adenylation of molybdopterin as part of the biosynthesis of the molybdenum-cofactor. molybdopterin. Kinetic parameters: KM=225 uM for ATP; Vmax=18.6 pmol/min/mg enzyme; Temperature dependence: Optimum temperature is >80 degrees Celsius; sp|Q8U3T3|MOAB_PYRFU;evalue=3e-022; PctID=40.71; score=104. (184 aa)    
Predicted Functional Partners:
moaC
Putative cyclic pyranopterin monophosphate synthase accessory protein; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family.
  
 0.995
MCBB_2265
Putative molybdopterin biosynthesis protein MJ0666; sp|Q58080|Y666_METJA;evalue=3e-077; PctID=42.22; score=289.
 
 0.984
Gphn
Gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step,molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. molybdopterin. molybdenum cofactor + AMP. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; SRGAP2 (via SH3 domain) (By similarity). Interacts with GLRB and GABARAP. P20236:Gabra3; NbExp=5; IntAct=E [...]
 
 0.981
MCBB_1200
Molybdopterin biosynthesis MoaE protein; tr|F6D658|F6D658_METPW;evalue=7e-062; PctID=82.07; score=242; {ECO:0000313|EMBL:AEG18271,1}.
 
 
 0.981
MCBB_1021
MOSC domain-containing protein; tr|A0A090JXS3|A0A090JXS3_METFO;evalue=2e-049; PctID=64.00; score=200; {ECO:0000313|EMBL:CEA14356,1}.
   
 0.923
moaA
Putative cyclic pyranopterin monophosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.
 
  
 0.906
MCBB_0010
Putative transcriptional regulator, ModE family; tr|F6D7C1|F6D7C1_METPW;evalue=2e-081; PctID=66.67; score=308; {ECO:0000313|EMBL:AEG17063,1}.
   
 
 0.805
MCBB_1067
MoaD family protein; tr|F6D3P5|F6D3P5_METPW;evalue=1e-032; PctID=74.73; score=144; {ECO:0000313|EMBL:AEG18039,1}.
  
  
 0.792
mobB
GTP-binding protein that is not required for the biosynthesis of Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor, and not necessary for the formation of active molybdoenzymes using this form of molybdenum cofactor. May act as an adapter protein to achieve the efficient biosynthesis and utilization of MGD. Displays a weak intrinsic GTPase activity. Is also able to bind the nucleotides ATP, TTP and GDP, but with lower affinity than GTP. Kinetic parameters: KM=7.5 uM for GTP; Note=kcat is 0.003 min(-1) for the GTPase activity; anaerobic growth conditions. Sequence=AAB02991.1; Type [...]
 
 
 
 0.685
hypA
Putative hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
   
   0.646
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
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