node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gphn | MCBB_0010 | MCBB_0305 | MCBB_0010 | Gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step,molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. molybdopterin. molybdenum cofactor + AMP. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; SRGAP2 (via SH3 domain) (By similarity). Interacts with GLRB and GABARAP. P20236:Gabra3; NbExp=5; IntAct=E [...] | Putative transcriptional regulator, ModE family; tr|F6D7C1|F6D7C1_METPW;evalue=2e-081; PctID=66.67; score=308; {ECO:0000313|EMBL:AEG17063,1}. | 0.726 |
Gphn | MCBB_1067 | MCBB_0305 | MCBB_1067 | Gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step,molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. molybdopterin. molybdenum cofactor + AMP. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; SRGAP2 (via SH3 domain) (By similarity). Interacts with GLRB and GABARAP. P20236:Gabra3; NbExp=5; IntAct=E [...] | MoaD family protein; tr|F6D3P5|F6D3P5_METPW;evalue=1e-032; PctID=74.73; score=144; {ECO:0000313|EMBL:AEG18039,1}. | 0.696 |
Gphn | MCBB_1200 | MCBB_0305 | MCBB_1200 | Gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step,molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. molybdopterin. molybdenum cofactor + AMP. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; SRGAP2 (via SH3 domain) (By similarity). Interacts with GLRB and GABARAP. P20236:Gabra3; NbExp=5; IntAct=E [...] | Molybdopterin biosynthesis MoaE protein; tr|F6D658|F6D658_METPW;evalue=7e-062; PctID=82.07; score=242; {ECO:0000313|EMBL:AEG18271,1}. | 0.700 |
Gphn | MCBB_2265 | MCBB_0305 | MCBB_2265 | Gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step,molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. molybdopterin. molybdenum cofactor + AMP. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; SRGAP2 (via SH3 domain) (By similarity). Interacts with GLRB and GABARAP. P20236:Gabra3; NbExp=5; IntAct=E [...] | Putative molybdopterin biosynthesis protein MJ0666; sp|Q58080|Y666_METJA;evalue=3e-077; PctID=42.22; score=289. | 0.930 |
Gphn | moaA | MCBB_0305 | MCBB_0122 | Gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step,molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. molybdopterin. molybdenum cofactor + AMP. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; SRGAP2 (via SH3 domain) (By similarity). Interacts with GLRB and GABARAP. P20236:Gabra3; NbExp=5; IntAct=E [...] | Putative cyclic pyranopterin monophosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. | 0.865 |
Gphn | moaB | MCBB_0305 | MCBB_1512 | Gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step,molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. molybdopterin. molybdenum cofactor + AMP. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; SRGAP2 (via SH3 domain) (By similarity). Interacts with GLRB and GABARAP. P20236:Gabra3; NbExp=5; IntAct=E [...] | Catalyzes the adenylation of molybdopterin as part of the biosynthesis of the molybdenum-cofactor. molybdopterin. Kinetic parameters: KM=225 uM for ATP; Vmax=18.6 pmol/min/mg enzyme; Temperature dependence: Optimum temperature is >80 degrees Celsius; sp|Q8U3T3|MOAB_PYRFU;evalue=3e-022; PctID=40.71; score=104. | 0.981 |
Gphn | moaC | MCBB_0305 | MCBB_0749 | Gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step,molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. molybdopterin. molybdenum cofactor + AMP. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; SRGAP2 (via SH3 domain) (By similarity). Interacts with GLRB and GABARAP. P20236:Gabra3; NbExp=5; IntAct=E [...] | Putative cyclic pyranopterin monophosphate synthase accessory protein; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. | 0.883 |
Gphn | mobB | MCBB_0305 | MCBB_0123 | Gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step,molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. molybdopterin. molybdenum cofactor + AMP. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; SRGAP2 (via SH3 domain) (By similarity). Interacts with GLRB and GABARAP. P20236:Gabra3; NbExp=5; IntAct=E [...] | GTP-binding protein that is not required for the biosynthesis of Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor, and not necessary for the formation of active molybdoenzymes using this form of molybdenum cofactor. May act as an adapter protein to achieve the efficient biosynthesis and utilization of MGD. Displays a weak intrinsic GTPase activity. Is also able to bind the nucleotides ATP, TTP and GDP, but with lower affinity than GTP. Kinetic parameters: KM=7.5 uM for GTP; Note=kcat is 0.003 min(-1) for the GTPase activity; anaerobic growth conditions. Sequence=AAB02991.1; Type [...] | 0.773 |
MCBB_0010 | Gphn | MCBB_0010 | MCBB_0305 | Putative transcriptional regulator, ModE family; tr|F6D7C1|F6D7C1_METPW;evalue=2e-081; PctID=66.67; score=308; {ECO:0000313|EMBL:AEG17063,1}. | Gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step,molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. molybdopterin. molybdenum cofactor + AMP. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; SRGAP2 (via SH3 domain) (By similarity). Interacts with GLRB and GABARAP. P20236:Gabra3; NbExp=5; IntAct=E [...] | 0.726 |
MCBB_0010 | MCBB_1067 | MCBB_0010 | MCBB_1067 | Putative transcriptional regulator, ModE family; tr|F6D7C1|F6D7C1_METPW;evalue=2e-081; PctID=66.67; score=308; {ECO:0000313|EMBL:AEG17063,1}. | MoaD family protein; tr|F6D3P5|F6D3P5_METPW;evalue=1e-032; PctID=74.73; score=144; {ECO:0000313|EMBL:AEG18039,1}. | 0.691 |
MCBB_0010 | MCBB_1200 | MCBB_0010 | MCBB_1200 | Putative transcriptional regulator, ModE family; tr|F6D7C1|F6D7C1_METPW;evalue=2e-081; PctID=66.67; score=308; {ECO:0000313|EMBL:AEG17063,1}. | Molybdopterin biosynthesis MoaE protein; tr|F6D658|F6D658_METPW;evalue=7e-062; PctID=82.07; score=242; {ECO:0000313|EMBL:AEG18271,1}. | 0.784 |
MCBB_0010 | MCBB_2265 | MCBB_0010 | MCBB_2265 | Putative transcriptional regulator, ModE family; tr|F6D7C1|F6D7C1_METPW;evalue=2e-081; PctID=66.67; score=308; {ECO:0000313|EMBL:AEG17063,1}. | Putative molybdopterin biosynthesis protein MJ0666; sp|Q58080|Y666_METJA;evalue=3e-077; PctID=42.22; score=289. | 0.726 |
MCBB_0010 | moaA | MCBB_0010 | MCBB_0122 | Putative transcriptional regulator, ModE family; tr|F6D7C1|F6D7C1_METPW;evalue=2e-081; PctID=66.67; score=308; {ECO:0000313|EMBL:AEG17063,1}. | Putative cyclic pyranopterin monophosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. | 0.849 |
MCBB_0010 | moaB | MCBB_0010 | MCBB_1512 | Putative transcriptional regulator, ModE family; tr|F6D7C1|F6D7C1_METPW;evalue=2e-081; PctID=66.67; score=308; {ECO:0000313|EMBL:AEG17063,1}. | Catalyzes the adenylation of molybdopterin as part of the biosynthesis of the molybdenum-cofactor. molybdopterin. Kinetic parameters: KM=225 uM for ATP; Vmax=18.6 pmol/min/mg enzyme; Temperature dependence: Optimum temperature is >80 degrees Celsius; sp|Q8U3T3|MOAB_PYRFU;evalue=3e-022; PctID=40.71; score=104. | 0.805 |
MCBB_0010 | moaC | MCBB_0010 | MCBB_0749 | Putative transcriptional regulator, ModE family; tr|F6D7C1|F6D7C1_METPW;evalue=2e-081; PctID=66.67; score=308; {ECO:0000313|EMBL:AEG17063,1}. | Putative cyclic pyranopterin monophosphate synthase accessory protein; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. | 0.789 |
MCBB_0010 | mobB | MCBB_0010 | MCBB_0123 | Putative transcriptional regulator, ModE family; tr|F6D7C1|F6D7C1_METPW;evalue=2e-081; PctID=66.67; score=308; {ECO:0000313|EMBL:AEG17063,1}. | GTP-binding protein that is not required for the biosynthesis of Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor, and not necessary for the formation of active molybdoenzymes using this form of molybdenum cofactor. May act as an adapter protein to achieve the efficient biosynthesis and utilization of MGD. Displays a weak intrinsic GTPase activity. Is also able to bind the nucleotides ATP, TTP and GDP, but with lower affinity than GTP. Kinetic parameters: KM=7.5 uM for GTP; Note=kcat is 0.003 min(-1) for the GTPase activity; anaerobic growth conditions. Sequence=AAB02991.1; Type [...] | 0.747 |
MCBB_1021 | moaB | MCBB_1021 | MCBB_1512 | MOSC domain-containing protein; tr|A0A090JXS3|A0A090JXS3_METFO;evalue=2e-049; PctID=64.00; score=200; {ECO:0000313|EMBL:CEA14356,1}. | Catalyzes the adenylation of molybdopterin as part of the biosynthesis of the molybdenum-cofactor. molybdopterin. Kinetic parameters: KM=225 uM for ATP; Vmax=18.6 pmol/min/mg enzyme; Temperature dependence: Optimum temperature is >80 degrees Celsius; sp|Q8U3T3|MOAB_PYRFU;evalue=3e-022; PctID=40.71; score=104. | 0.923 |
MCBB_1021 | moaC | MCBB_1021 | MCBB_0749 | MOSC domain-containing protein; tr|A0A090JXS3|A0A090JXS3_METFO;evalue=2e-049; PctID=64.00; score=200; {ECO:0000313|EMBL:CEA14356,1}. | Putative cyclic pyranopterin monophosphate synthase accessory protein; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. | 0.940 |
MCBB_1067 | Gphn | MCBB_1067 | MCBB_0305 | MoaD family protein; tr|F6D3P5|F6D3P5_METPW;evalue=1e-032; PctID=74.73; score=144; {ECO:0000313|EMBL:AEG18039,1}. | Gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step,molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. molybdopterin. molybdenum cofactor + AMP. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; SRGAP2 (via SH3 domain) (By similarity). Interacts with GLRB and GABARAP. P20236:Gabra3; NbExp=5; IntAct=E [...] | 0.696 |
MCBB_1067 | MCBB_0010 | MCBB_1067 | MCBB_0010 | MoaD family protein; tr|F6D3P5|F6D3P5_METPW;evalue=1e-032; PctID=74.73; score=144; {ECO:0000313|EMBL:AEG18039,1}. | Putative transcriptional regulator, ModE family; tr|F6D7C1|F6D7C1_METPW;evalue=2e-081; PctID=66.67; score=308; {ECO:0000313|EMBL:AEG17063,1}. | 0.691 |