Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MCBB_1663Heat shock protein Hsp20; tr|F6D4F0|F6D4F0_METPW;evalue=3e-038; PctID=58.33; score=163; {ECO:0000313|EMBL:AEG18813,1}; Belongs to the small heat shock protein (HSP20) family. (144 aa)    
Predicted Functional Partners:
hsp16
Heat shock protein 16; sp|O14368|HSP16_SCHPO;evalue=1e-009; PctID=36.00; score=62.0; Belongs to the small heat shock protein (HSP20) family.
  
  
 
0.906
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 
 0.904
dnaK
Chaperone protein DnaK; Acts as a chaperone.
  
 
 0.857
grpE
Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.800
glnA
Glutamine synthetase; sp|O27612|GLNA_METTH;evalue=0.0; PctID=75.11; score=711; Belongs to the glutamine synthetase family.
   
 
 0.730
rpl10e
50S ribosomal protein L10e; sp|O27191|RL10E_METTH;evalue=4e-073; PctID=80.00; score=273; {ECO:0000255|HAMAP-Rule:MF_00448}; Belongs to the universal ribosomal protein uL16 family.
  
 
 0.675
pfdB
Prefoldin subunit beta; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
      
 0.668
MCBB_0144
ABC transporter substrate-binding protein; tr|K2RWF3|K2RWF3_METFO;evalue=7e-128; PctID=68.81; score=463; {ECO:0000313|EMBL:EKF87110,1}.
      
 0.638
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
   
 
 0.628
MCBB_2172
Transcriptional regulator, ArsR family; tr|F0T871|F0T871_METLA;evalue=1e-055; PctID=79.29; score=221; {ECO:0000313|EMBL:ADZ08483,1}.
     
 0.467
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
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