STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mvhAF420-non-reducing hydrogenase subunit A; Part of a complex that provides reducing equivalents for heterodisulfide reductase. Name=Ni(2+); Xref=ChEBI:CHEBI:49786; Evidence=; subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (hdr). subunit family; sp|P60227|MVHA_METTM;evalue=0.0; PctID=81.36; score=791; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (470 aa)    
Predicted Functional Partners:
mvhG
F420-non-reducing hydrogenase subunit G; Part of a complex that provides reducing equivalents for heterodisulfide reductase. subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (hdr). subunit family; sp|P60239|MVHG_METTM;evalue=5e-146; PctID=79.29; score=517.
 
 0.999
mvhD
F420-non-reducing hydrogenase iron-sulfur subunit D; Part of a complex that provides reducing equivalents for heterodisulfide reductase. MvhD may form the contact site to heterodisulfide reductase (By similarity). Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence=; Note=Binds 1 [2Fe-2S] cluster; subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (hdr) (By similarity); sp|Q50781|MVHD_METTH;evalue=3e-072; PctID=90.65; score=270.
  
 0.998
vhuG
F420-non-reducing hydrogenase vhu subunit G; sp|Q58591|VHUG_METJA;evalue=3e-052; PctID=39.25; score=205.
 
 0.996
hdrB3
CoB-CoM heterodisulfide reductase subunit B; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrB may have a function in energy transduction. N-(7-((2-sulfoethyl)dithio)heptanoyl)-O(3)-phospho-L- threonine + dihydromethanophenazine. heterodisulfide reduction; coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1. subunits; HdrA, HdrB and HdrC. It forms a complex with the F420-non-reducing hydrogenase (Mvh), which provides the reducing equivalents to the heterodisulfid [...]
  
 0.992
hdrC3
CoB-CoM heterodisulfide reductase iron-sulfur subunit C; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrC may carry electrons from hydrogenase to HdrA. N-(7-((2-sulfoethyl)dithio)heptanoyl)-O(3)-phospho-L- threonine + dihydromethanophenazine. Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 2 [4Fe-4S] clusters per subunit; heterodisulfide reduction; coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1. subunits; HdrA, HdrB and HdrC. It forms a [...]
  
 0.992
hdrA3
CoB-CoM heterodisulfide reductase iron-sulfur subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
  
 0.992
vhcD
F420-non-reducing hydrogenase vhc iron-sulfur subunit D; sp|Q00405|VHCD_METVO;evalue=7e-049; PctID=61.59; score=192.
  
 0.988
hypA
Putative hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.973
frhG
Coenzyme F420 hydrogenase subunit gamma; Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen. coenzyme F420. Name=Ni(2+); Xref=ChEBI:CHEBI:49786; Name=iron-sulfur cluster; Xref=ChEBI:CHEBI:30408; Note=There are 12-13 Fe atoms per alpha/beta/gamma unit of the FRH; Name=FAD; Xref=ChEBI:CHEBI:57692; Sequence=AAB85778.1; Type=Erroneous initiation; Evidence=; sp|P19498|FRHG_METTH;evalue=7e-121; PctID=87.83; score=433.
 
 
 0.971
mvhB
Polyferredoxin protein MvhB; sp|Q50784|MVHB_METTH;evalue=0.0; PctID=78.45; score=721.
  
  
 0.961
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.