STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MCBB_1970UPF0051 protein; sp|Q50519|YB50_METTW;evalue=2e-175; PctID=73.66; score=615. (406 aa)    
Predicted Functional Partners:
MCBB_1969
Putative ABC transporter ATP-binding protein spyM18_0273; sp|Q8P2M5|Y273_STRP8;evalue=8e-043; PctID=39.76; score=174.
 
 0.999
csd
Putative cysteine desulfurase; sp|O27442|CSD_METTH;evalue=5e-147; PctID=63.08; score=521.
 
 0.998
iscU2
Iron-sulfur cluster assembly scaffold protein IscU 2; A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. Binds 1 2Fe-2S cluster per subunit in a crystal formed under reducing conditions; this subunit provides 3 ligands while IscS2 provides the other ligand. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters; sp|P0DMG1|ISCU1_ARCFU,sp|P0DMG2|ISCU2_ARCFU; evalue=1e-043; PctID=67.97; score=174.
  
  
 0.983
iscS
Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
 
  
 0.610
copA
Copper-exporting P-type ATPase A; Involved in copper export. + Cu(+)(Side 2). Homodimer at higher copper concentrations. Forms a heterodimer (electrostatic interactions) with CopZ during the transfer of Cu(+). Self; NbExp=2; IntAct=EBI-905041,EBI-905041; indirectly repressed by YfmP. (TC 3.A.3) family. Type IB subfamily. ProRule:PRU00280}; sp|O32220|COPA_BACSU;evalue=2e-169; PctID=41.54; score=596.
     
 0.517
cysE
Catalyzes the acetylation of serine by acetyl-CoA to produce O-acetylserine (OAS). serine. cysteine from L-serine: step 1/2; sp|Q06750|CYSE_BACSU;evalue=1e-060; PctID=57.49; score=233.
     
 0.490
MCBB_1186
Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  
  
 0.472
tarI
Putative ribitol-5-phosphate cytidylyltransferase; Provides activated ribitol phosphate for teichoic acid synthesis. CDP-ribitol. acid biosynthesis; sp|Q8RKI9|TARI_BACPZ;evalue=1e-075; PctID=56.22; score=282.
  
  
 0.440
fae-hps-2
Bifunctional enzyme Fae/Hps; Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate. = 5,10-methylenetetrahydromethanopterin + H(2)O. 5-phosphate + formaldehyde. biosynthesis. formaldehyde-activating enzyme family. family. HPS subfamily. Sequence=AAB85949.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Evidence=; sp|O27518|FAEHP_METTH;evalue=6e-049; PctID=58.75; score=192; {ECO:0000255|HAMAP-Rule:MF_01268}.
       0.440
MCBB_0710
Putative threonylcarbamoyladenosine tRNA methylthiotransferase; Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + reduced electron acceptor = 2-methylthio-N(6)-L-threonylcarbamoyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + electron acceptor. Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=B [...]
 
   
 0.435
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
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