STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MCBB_2078Putative protein MJ0653; sp|Q58069|Y653_METJA;evalue=1e-027; PctID=36.93; score=122. (185 aa)    
Predicted Functional Partners:
MCBB_2076
Putative protein MJ1225; sp|Q58622|Y1225_METJA;evalue=2e-055; PctID=39.72; score=216.
 
   
0.946
MCBB_2077
CBS domain containing protein; tr|F6D3G6|F6D3G6_METPW;evalue=3e-094; PctID=64.58; score=351; {ECO:0000313|EMBL:AEG19142,1}.
 
     0.909
queE
7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
       0.784
GR
Maintains high levels of reduced glutathione in the chloroplast. disulfide + NADPH. Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence=; Note=Binds 1 FAD per subunit; Mitochondrion Note=The majority of the protein is found in chloroplast, with only 3% in mitochondria. oxidoreductase family. Sequence=CAA42921.1; Type=Erroneous initiation; Evidence=; sp|P27456|GSHRP_PEA;evalue=6e-028; PctID=26.09; score=125.
  
 
 0.740
queD
Putative 6-carboxy-5,6,7,8-tetrahydropterin synthase; Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit; subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit (By similarity); sp|O27296|QUED_METTH;evalue=1e-058; PctID=69.18; score=225.
       0.727
pspE
Thiosulfate sulfurtransferase PspE; The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient-or energy-limited conditions. PspE catalyzes the sulfur-transfer reaction from thiosulfate to cyanide,to form sulfite and thiocyanate. Also able to use dithiol (dithiothreitol) as an alternate sulfur acceptor. Also possesses a very low mercaptopyruvate sulfurtransferase activity. particularly at low cyanide concentrations (<5 mM). Inhibited by sodium sulfate or sodium chloride at 0.25 M which gives around 50% inhibition of rhodan [...]
   
 
 0.662
hagh
Hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. glutathione + a 2-hydroxy carboxylate. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 2 Zn(2+) ions per subunit; degradation; (R)-lactate from methylglyoxal: step 2/2. Glyoxalase II family; sp|Q54MR1|GLO2_DICDI;evalue=5e-008; PctID=26.76; score=59.7.
   
 
 0.662
yqhL
Putative protein YqhL; sp|P54510|YQHL_BACSU;evalue=8e-008; PctID=35.53; score=55.8.
   
 
 0.662
MCBB_0422
Putative protein MJ0653; sp|Q58069|Y653_METJA;evalue=3e-007; PctID=30.88; score=55.8.
 
    0.621
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. xanthosine 5'-phosphate + NADH. Name=K(+); Xref=ChEBI:CHEBI:29103; Evidence=; inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformat [...]
  
     0.615
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
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