STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa)    
Predicted Functional Partners:
hacA
Putative methanogen homoaconitase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.999
leuC
Putative 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.999
leuB3
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity). 2-oxopentanoate + CO(2) + NADH. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit; leucine from 3-methyl-2-oxobutanoate: step 3/4. dehydrogenases family; sp|O27441|LEU3_METTH;evalue=1e-117; PctID=64.92; score=423.
 
 
 0.993
leuA
Putative 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). (2S)-2-isopropylmalate + CoA. leucine from 3-methyl-2-oxobutanoate: step 1/4. family; sp|O27525|LEU1_METTH;evalue=0.0; PctID=76.89; score=776; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.969
cimA
Putative (R)-citramalate synthase CimA; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.969
ilvD
Dihydroxy-acid dehydratase; sp|O27498|ILVD_METTH;evalue=0.0; PctID=71.14; score=819; {ECO:0000255|HAMAP-Rule:MF_00012}; Belongs to the IlvD/Edd family.
  
  
 0.929
leuB1
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity). 2-oxopentanoate + CO(2) + NADH. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit; leucine from 3-methyl-2-oxobutanoate: step 3/4. dehydrogenases family; sp|O27441|LEU3_METTH;evalue=2e-108; PctID=62.04; score=392.
 
  
 0.899
ydaP
Putative thiamine pyrophosphate-containing protein YdaP; sp|P96591|YDAP_BACSU;evalue=5e-106; PctID=40.30; score=385; Belongs to the TPP enzyme family.
  
 
 0.895
pycA
Pyruvate carboxylase catalyzes a 2-step reaction,involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. oxaloacetate. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828; pH dependence: Optimum pH is 8; Temperature dependence: Optimum temperature is 60 degrees Celsius.; ProRule:PRU00409}; sp|O27939|PYCA_METTH;evalue=0.0; PctID=76.54; score=767.
  
 
 0.860
thrC
Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
  
  
 0.857
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
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