| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| L21_0178 | apt | L21_0178 | L21_0179 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Adenine phosphoribosyltransferase. | 0.909 |
| L21_0178 | fsr | L21_0178 | L21_0176 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Fosmidomycin resistance protein. | 0.860 |
| L21_0178 | gadB | L21_0178 | L21_0180 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Glutamate decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. | 0.826 |
| L21_0178 | ppsA_1 | L21_0178 | L21_0181 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | 0.822 |
| L21_0178 | prmA_2 | L21_0178 | L21_0177 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Ribosomal protein L11 methyltransferase. | 0.916 |
| L21_0178 | serA | L21_0178 | L21_0182 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.569 |
| L21_0178 | ubiB | L21_0178 | L21_0175 | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Putative ubiquinone biosynthesis protein UbiB. | 0.641 |
| apt | L21_0178 | L21_0179 | L21_0178 | Adenine phosphoribosyltransferase. | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.909 |
| apt | fsr | L21_0179 | L21_0176 | Adenine phosphoribosyltransferase. | Fosmidomycin resistance protein. | 0.860 |
| apt | gadB | L21_0179 | L21_0180 | Adenine phosphoribosyltransferase. | Glutamate decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. | 0.837 |
| apt | ndk | L21_0179 | L21_2207 | Adenine phosphoribosyltransferase. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.619 |
| apt | ppsA_1 | L21_0179 | L21_0181 | Adenine phosphoribosyltransferase. | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | 0.803 |
| apt | prmA_2 | L21_0179 | L21_0177 | Adenine phosphoribosyltransferase. | Ribosomal protein L11 methyltransferase. | 0.902 |
| apt | serA | L21_0179 | L21_0182 | Adenine phosphoribosyltransferase. | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.609 |
| apt | thyA1 | L21_0179 | L21_2419 | Adenine phosphoribosyltransferase. | Thymidylate synthase 1; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. | 0.483 |
| apt | ubiB | L21_0179 | L21_0175 | Adenine phosphoribosyltransferase. | Putative ubiquinone biosynthesis protein UbiB. | 0.756 |
| fsr | L21_0178 | L21_0176 | L21_0178 | Fosmidomycin resistance protein. | Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.860 |
| fsr | apt | L21_0176 | L21_0179 | Fosmidomycin resistance protein. | Adenine phosphoribosyltransferase. | 0.860 |
| fsr | gadB | L21_0176 | L21_0180 | Fosmidomycin resistance protein. | Glutamate decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily. | 0.787 |
| fsr | gapB | L21_0176 | L21_0720 | Fosmidomycin resistance protein. | Glyceraldehyde-3-phosphate dehydrogenase 2. | 0.483 |