STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
L21_0830hydroxymethylglutaryl-CoA reductase (NADPH); Belongs to the HMG-CoA reductase family. (402 aa)    
Predicted Functional Partners:
pqsD
PQB biosynthetic 3-oxoacyl-[acyl-carrier-protein] synthase III; Belongs to the thiolase-like superfamily. UPF0219 family.
 
 0.999
mvk
Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
 
 0.996
L21_0805
1, 4-dihydroxy-2-naphthoateoctaprenyltransferase.
   
 
 0.916
L21_0831
Putative methyltransferase.
 
     0.761
L21_0833
Putative acetyl-CoA acyltransferase.
 
  
 0.708
leuA_1
2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
    
 0.692
leuA_2
2-isopropylmalate synthase.
    
 0.692
leuA_3
2-isopropylmalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family.
    
 0.692
L21_0832
Putative nucleic-acid-binding protein containing a Zn-ribbon.
    
  0.671
fni
Isopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
 
   
 0.660
Your Current Organism:
Methanoculleus chikugoensis
NCBI taxonomy Id: 118126
Other names: DSM 13459, JCM 10825, M. chikugoensis, Methaniculleus sp. MG62, Methanoculleus chikugoensis Dianou et al. 2001, Methanoculleus sp. MG62, NBRC 101202, strain MG62
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.