STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topADNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (931 aa)    
Predicted Functional Partners:
L21_1327
Hypothetical protein.
    
 0.969
recQ_2
ATP-dependent DNA helicase RecQ.
 
 0.959
recQ_3
ATP-dependent DNA helicase RecQ.
 
 0.959
recQ_4
ATP-dependent DNA helicase RecQ.
  
 0.959
dbpA
ATP-dependent RNA helicase DbpA.
  
 0.954
L21_0840
Replication factor A.
 
 0.948
L21_1706
Putative DNA double-strand break repair Rad50 ATPase.
 
 0.946
L21_0259
Replication factor A.
  
 0.922
L21_0922
Putative tRNA/rRNA methyltransferase.
 
     0.921
pcrB
Heptaprenylglyceryl phosphate synthase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
  
    0.912
Your Current Organism:
Methanoculleus chikugoensis
NCBI taxonomy Id: 118126
Other names: DSM 13459, JCM 10825, M. chikugoensis, Methaniculleus sp. MG62, Methanoculleus chikugoensis Dianou et al. 2001, Methanoculleus sp. MG62, NBRC 101202, strain MG62
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.