EDX72366.1 protein (Coleofasciculus chthonoplastes)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

EDX72366.1

PAS fold family; [T] COG0642 Signal transduction histidine kinase. (1821 aa)

Predicted Functional Partners:

EDX70818.1

0.999

EDX70848.1

0.999

EDX76978.1

0.999

EDX75162.1

0.999

EDX72559.1

0.999

EDX71158.1

0.999

EDX76526.1

0.999

EDX72708.1

0.999

EDX77984.1

0.999

EDX75323.1

0.998

Your Current Organism:

Coleofasciculus chthonoplastes

NCBI taxonomy Id: 118168
Other names: C. chthonoplastes PCC 7420, Coleofasciculus chthonoplastes PCC 7420, Microcoleus chthonoplastes PCC 7420, Microcoleus sp. PCC 7420

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDX70818.1	EDX70848.1	MC7420_107	MC7420_137	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	0.999
EDX70818.1	EDX71158.1	MC7420_107	MC7420_2719	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	Hypothetical protein; [T] COG0784 FOG: CheY-like receiver; response regulator receiver domain, putative.	0.999
EDX70818.1	EDX72366.1	MC7420_107	MC7420_1035	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70818.1	EDX72559.1	MC7420_107	MC7420_2467	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70818.1	EDX72708.1	MC7420_107	MC7420_4981	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70818.1	EDX75162.1	MC7420_107	MC7420_2166	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	GAF domain protein; [T] COG0784 FOG: CheY-like receiver.	0.999
EDX70818.1	EDX75323.1	MC7420_107	MC7420_1241	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70818.1	EDX76526.1	MC7420_107	MC7420_4782	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70818.1	EDX76978.1	MC7420_107	MC7420_1981	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70818.1	EDX77984.1	MC7420_107	MC7420_7722	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	PAS fold family; [T] COG2203 FOG: GAF domain.	0.999
EDX70848.1	EDX70818.1	MC7420_137	MC7420_107	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70848.1	EDX71158.1	MC7420_137	MC7420_2719	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	Hypothetical protein; [T] COG0784 FOG: CheY-like receiver; response regulator receiver domain, putative.	0.999
EDX70848.1	EDX72366.1	MC7420_137	MC7420_1035	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70848.1	EDX72559.1	MC7420_137	MC7420_2467	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70848.1	EDX72708.1	MC7420_137	MC7420_4981	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70848.1	EDX75162.1	MC7420_137	MC7420_2166	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	GAF domain protein; [T] COG0784 FOG: CheY-like receiver.	0.999
EDX70848.1	EDX75323.1	MC7420_137	MC7420_1241	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70848.1	EDX76526.1	MC7420_137	MC7420_4782	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70848.1	EDX76978.1	MC7420_137	MC7420_1981	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70848.1	EDX77984.1	MC7420_137	MC7420_7722	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	PAS fold family; [T] COG2203 FOG: GAF domain.	0.999

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Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.865

expected number of edges:

11

PPI enrichment p-value:

0.000495

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006368

Transcription elongation from RNA polymerase II promoter

6 of 24

2.31

4.32

1.40e-09

GO:0016570

Histone modification

6 of 92

1.72

2.48

7.50e-07

GO:0032968

Positive regulation of transcription elongation from RNA polymerase II promoter

3 of 13

2.27

1.94

0.00020

GO:0034402

Recruitment of 3-end processing factors to RNA polymerase II holoenzyme complex

2 of 5

2.51

1.32

0.0038

GO:0070478

Nuclear-transcribed mRNA catabolic process, 3-5 exonucleolytic nonsense-mediated decay

2 of 8

2.31

1.15

0.0074

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000993

RNA polymerase II complex binding

6 of 14

2.54

5.28

3.99e-11

GO:0005515

Protein binding

8 of 738

0.94

0.91

6.82e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016593

Cdc73/Paf1 complex

6 of 8

2.78

6.18

1.66e-12

GO:0055087

Ski complex

2 of 3

2.73

1.65

0.00096

GO:0032991

Protein-containing complex

10 of 1771

0.66

0.58

8.35e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1768

RNA Polymerase II Transcription Elongation

6 of 28

2.24

4.23

1.43e-09

CL:1810

Cdc73/Paf1 complex

4 of 6

2.73

3.73

1.06e-07

CL:681

COP9 signalosome, and Cul4-RING E3 ubiquitin ligase complex

3 of 20

2.08

1.72

0.00044

CL:5095

mRNA decay by 3 to 5 exoribonuclease

2 of 17

1.98

0.8

0.0316

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-75955

RNA Polymerase II Transcription Elongation

6 of 43

2.05

3.65

8.49e-09

MAP-674695

RNA Polymerase II Pre-transcription Events

6 of 67

1.86

3.06

5.11e-08

MAP-73857

RNA Polymerase II Transcription

6 of 389

1.1

0.95

0.00087

MAP-74160

Gene expression (Transcription)

6 of 523

0.97

0.73

0.0035

MAP-8866654

E3 ubiquitin ligases ubiquitinate target proteins

2 of 17

1.98

0.73

0.0435

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016593

Cdc73/Paf1 complex

6 of 8

2.78

6.15

1.92e-12

GOCC:0055087

Ski complex

2 of 2

2.91

1.71

0.00080

GOCC:0032991

Protein-containing complex

9 of 2171

0.53

0.38

0.0083

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