EDX71144.1 protein (Coleofasciculus chthonoplastes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EDX71144.1

Cyclic diguanylate phosphodiesterase (EAL) domain protein; [T] COG2200 FOG: EAL domain. (560 aa)

Predicted Functional Partners:

EDX70848.1

0.999

EDX76978.1

0.999

EDX72559.1

0.999

EDX76526.1

0.999

EDX72708.1

0.999

EDX77984.1

0.999

EDX78539.1

0.996

EDX77647.1

0.995

EDX70818.1

0.994

EDX74378.1

0.994

Your Current Organism:

Coleofasciculus chthonoplastes

NCBI taxonomy Id: 118168
Other names: C. chthonoplastes PCC 7420, Coleofasciculus chthonoplastes PCC 7420, Microcoleus chthonoplastes PCC 7420, Microcoleus sp. PCC 7420

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDX70818.1	EDX70848.1	MC7420_107	MC7420_137	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	0.999
EDX70818.1	EDX71144.1	MC7420_107	MC7420_4331	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	Cyclic diguanylate phosphodiesterase (EAL) domain protein; [T] COG2200 FOG: EAL domain.	0.994
EDX70818.1	EDX72559.1	MC7420_107	MC7420_2467	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70818.1	EDX72708.1	MC7420_107	MC7420_4981	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70818.1	EDX74378.1	MC7420_107	MC7420_3902	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70818.1	EDX76526.1	MC7420_107	MC7420_4782	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70818.1	EDX76978.1	MC7420_107	MC7420_1981	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70818.1	EDX77647.1	MC7420_107	MC7420_2971	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70818.1	EDX77984.1	MC7420_107	MC7420_7722	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	PAS fold family; [T] COG2203 FOG: GAF domain.	0.999
EDX70818.1	EDX78539.1	MC7420_107	MC7420_7192	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	0.999
EDX70848.1	EDX70818.1	MC7420_137	MC7420_107	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	GAF domain protein; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70848.1	EDX71144.1	MC7420_137	MC7420_4331	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	Cyclic diguanylate phosphodiesterase (EAL) domain protein; [T] COG2200 FOG: EAL domain.	0.999
EDX70848.1	EDX72559.1	MC7420_137	MC7420_2467	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70848.1	EDX72708.1	MC7420_137	MC7420_4981	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70848.1	EDX74378.1	MC7420_137	MC7420_3902	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70848.1	EDX76526.1	MC7420_137	MC7420_4782	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70848.1	EDX76978.1	MC7420_137	MC7420_1981	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70848.1	EDX77647.1	MC7420_137	MC7420_2971	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	PAS fold family; [T] COG0642 Signal transduction histidine kinase.	0.999
EDX70848.1	EDX77984.1	MC7420_137	MC7420_7722	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	PAS fold family; [T] COG2203 FOG: GAF domain.	0.999
EDX70848.1	EDX78539.1	MC7420_137	MC7420_7192	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	Response regulator receiver domain protein; [T] COG0784 FOG: CheY-like receiver.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.785

expected number of edges:

10

PPI enrichment p-value:

1.38e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006810

Transport

11 of 296

0.87

0.94

3.41e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022857

Transmembrane transporter activity

10 of 224

0.95

1.05

8.03e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

7 of 294

0.68

0.48

0.0090

GO:0016020

Membrane

11 of 638

0.54

0.46

0.00014

GO:0016021

Integral component of membrane

8 of 435

0.57

0.41

0.0090

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3162

Palmitate, and RND efflux pump, membrane fusion protein

9 of 13

2.14

6.11

1.80e-15

CL:3160

Mixed, incl. Outer membrane efflux protein, and RND efflux pump, membrane fusion protein

10 of 22

1.96

5.53

4.22e-16

CL:3164

Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains, and RND efflux pump, membrane fusion protein, barrel-sandwich domain

5 of 7

2.16

3.48

5.43e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01501

beta-Lactam resistance

5 of 46

1.34

1.3

0.00025

map01503

Cationic antimicrobial peptide (CAMP) resistance

4 of 37

1.34

1.09

0.0017

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990281

Efflux pump complex

5 of 5

2.3

3.6

6.24e-08

GOCC:0098567

Periplasmic side of plasma membrane

5 of 8

2.1

3.22

1.58e-07

GOCC:0005886

Plasma membrane

10 of 277

0.86

0.91

6.69e-07

GOCC:0016020

Membrane

11 of 418

0.72

0.71

6.69e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0175

Coiled coil

6 of 177

0.83

0.6

0.0061

KW-0812

Transmembrane

9 of 415

0.64

0.49

0.0023

KW-1133

Transmembrane helix

8 of 397

0.61

0.44

0.0061

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13533

Biotin-lipoyl like

4 of 5

2.21

2.47

1.36e-05

PF13437

HlyD family secretion protein

3 of 4

2.18

1.71

0.00052

PF03176

MMPL family

3 of 5

2.08

1.67

0.00056

PF16576

Barrel-sandwich domain of CusB or HlyD membrane-fusion

2 of 2

2.3

1.06

0.0111

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR027463

Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains

4 of 4

2.3

2.43

2.01e-05

IPR006143

RND efflux pump, membrane fusion protein

4 of 4

2.3

2.43

2.01e-05

IPR001036

Acriflavin resistance protein

4 of 5

2.21

2.39

2.01e-05

IPR032317

RND efflux pump, membrane fusion protein, barrel-sandwich domain

3 of 3

2.3

1.8

0.00040

IPR039562

Membrane fusion protein, biotin-lipoyl like domain

2 of 3

2.13

0.76

0.0393

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (16%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About