EDX70734.1 protein (Coleofasciculus chthonoplastes)

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second shell of interactors

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Predicted Interactions

gene neighborhood

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Score

EDX70734.1

HNH endonuclease domain protein; [V] COG1403 Restriction endonuclease. (142 aa)

Predicted Functional Partners:

EDX70735.1

0.773

EDX70732.1

0.715

EDX76406.1

0.598

EDX78214.1

0.588

EDX78125.1

0.579

EDX76635.1

0.567

EDX77355.1

0.559

EDX70548.1

0.554

EDX73634.1

0.550

EDX75826.1

0.546

Your Current Organism:

Coleofasciculus chthonoplastes

NCBI taxonomy Id: 118168
Other names: C. chthonoplastes PCC 7420, Coleofasciculus chthonoplastes PCC 7420, Microcoleus chthonoplastes PCC 7420, Microcoleus sp. PCC 7420

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDX70548.1	EDX70732.1	MC7420_8075	MC7420_8160	XisH protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	XisI protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.774
EDX70548.1	EDX70734.1	MC7420_8075	MC7420_8162	XisH protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	HNH endonuclease domain protein; [V] COG1403 Restriction endonuclease.	0.554
EDX70548.1	EDX73634.1	MC7420_8075	MC7420_6682	XisH protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	XisI protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.775
EDX70548.1	EDX75826.1	MC7420_8075	MC7420_6481	XisH protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	XisI protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.775
EDX70548.1	EDX76635.1	MC7420_8075	MC7420_4891	XisH protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	XisI protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.775
EDX70548.1	EDX77355.1	MC7420_8075	MC7420_492	XisH protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	XisI protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.775
EDX70548.1	EDX78214.1	MC7420_8075	MC7420_7952	XisH protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	XisI protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.775
EDX70732.1	EDX70548.1	MC7420_8160	MC7420_8075	XisI protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	XisH protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.774
EDX70732.1	EDX70734.1	MC7420_8160	MC7420_8162	XisI protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	HNH endonuclease domain protein; [V] COG1403 Restriction endonuclease.	0.715
EDX70732.1	EDX76406.1	MC7420_8160	MC7420_4662	XisI protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	XisH protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.775
EDX70732.1	EDX78125.1	MC7420_8160	MC7420_7863	XisI protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	XisH protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.775
EDX70734.1	EDX70548.1	MC7420_8162	MC7420_8075	HNH endonuclease domain protein; [V] COG1403 Restriction endonuclease.	XisH protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.554
EDX70734.1	EDX70732.1	MC7420_8162	MC7420_8160	HNH endonuclease domain protein; [V] COG1403 Restriction endonuclease.	XisI protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.715
EDX70734.1	EDX70735.1	MC7420_8162	MC7420_8163	HNH endonuclease domain protein; [V] COG1403 Restriction endonuclease.	Hypothetical protein.	0.773
EDX70734.1	EDX73634.1	MC7420_8162	MC7420_6682	HNH endonuclease domain protein; [V] COG1403 Restriction endonuclease.	XisI protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.550
EDX70734.1	EDX75826.1	MC7420_8162	MC7420_6481	HNH endonuclease domain protein; [V] COG1403 Restriction endonuclease.	XisI protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.546
EDX70734.1	EDX76406.1	MC7420_8162	MC7420_4662	HNH endonuclease domain protein; [V] COG1403 Restriction endonuclease.	XisH protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.598
EDX70734.1	EDX76635.1	MC7420_8162	MC7420_4891	HNH endonuclease domain protein; [V] COG1403 Restriction endonuclease.	XisI protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.567
EDX70734.1	EDX77355.1	MC7420_8162	MC7420_492	HNH endonuclease domain protein; [V] COG1403 Restriction endonuclease.	XisI protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.559
EDX70734.1	EDX78125.1	MC7420_8162	MC7420_7863	HNH endonuclease domain protein; [V] COG1403 Restriction endonuclease.	XisH protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.579

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Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.749

expected number of edges:

16

PPI enrichment p-value:

0.37

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009064

Glutamine family amino acid metabolic process

4 of 59

1.78

1.35

0.0017

GO:0019240

Citrulline biosynthetic process

2 of 2

2.95

1.26

0.0052

GO:0006228

UTP biosynthetic process

2 of 3

2.78

1.23

0.0058

GO:1901607

Alpha-amino acid biosynthetic process

4 of 113

1.5

1.03

0.0052

GO:0006207

De novo pyrimidine nucleobase biosynthetic process

2 of 9

2.3

0.99

0.0147

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

4 of 54

1.82

1.58

0.00052

GO:0004070

Aspartate carbamoyltransferase activity

2 of 2

2.95

1.36

0.0035

GO:0004151

Dihydroorotase activity

2 of 3

2.78

1.3

0.0043

GO:0004088

Carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

2 of 3

2.78

1.3

0.0043

GO:0016884

Carbon-nitrogen ligase activity, with glutamine as amido-N-donor

3 of 28

1.98

1.26

0.0035

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031417

NatC complex

3 of 4

2.83

2.47

3.02e-05

GO:0005687

U4 snRNP

2 of 5

2.55

1.19

0.0066

GO:0005682

U5 snRNP

2 of 12

2.17

0.99

0.0143

GO:0005685

U1 snRNP

2 of 14

2.11

0.96

0.0161

GO:0005686

U2 snRNP

2 of 20

1.95

0.83

0.0270

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15221

NatC complex, and Aspartate and asparagine metabolism

3 of 5

2.73

2.18

0.00010

CL:9359

Arginine biosynthetic process

3 of 11

2.39

1.86

0.00033

CL:9347

Mixed, incl. Glutamine family amino acid metabolic process, and Cyanoamino acid metabolism

4 of 65

1.74

1.57

0.00041

CL:5296

Spliceosomal snRNP complex, and SLBP independent Processing of Histone Pre-mRNAs

3 of 40

1.83

1.35

0.0018

CL:5306

U4 snRNP, and U1 snRNP

2 of 6

2.48

1.32

0.0037

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00250

Alanine, aspartate and glutamate metabolism

5 of 59

1.88

2.72

6.59e-07

map03040

Spliceosome

4 of 149

1.38

1.16

0.0013

map00220

Arginine biosynthesis

2 of 35

1.71

0.73

0.0370

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8963693

Aspartate and asparagine metabolism

3 of 14

2.28

1.69

0.00065

MAP-6811440

Retrograde transport at the Trans-Golgi-Network

3 of 33

1.91

1.25

0.0034

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031417

NatC complex

3 of 6

2.65

2.21

8.34e-05

GOCC:0005687

U4 snRNP

2 of 4

2.65

1.24

0.0055

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0315

Glutamine amidotransferase

2 of 12

2.17

0.87

0.0242

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02786

Carbamoyl-phosphate synthase L chain, ATP binding domain

2 of 4

2.65

0.98

0.0170

PF07478

D-ala D-ala ligase C-terminus

2 of 5

2.55

0.97

0.0170

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR047575

Sm domain

3 of 16

2.23

1.36

0.0028

IPR001163

Sm domain, eukaryotic/archaea-type

3 of 16

2.23

1.36

0.0028

IPR010920

LSM domain superfamily

3 of 19

2.15

1.35

0.0028

IPR036914

Methylglyoxal synthase-like domain superfamily

2 of 3

2.78

1.28

0.0048

IPR036897

Carbamoyl-phosphate synthetase, large subunit oligomerisation domain superfamily

2 of 2

2.95

1.28

0.0048

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00651

snRNP Sm proteins

3 of 16

2.23

1.83

0.00032

SM01096

Carbamoyl-phosphate synthetase large chain, oligomerisation domain

2 of 2

2.95

1.63

0.0011

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