N307_05475 protein (Picoides pubescens) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

N307_05475

Collagen alpha-3(VI) chain. (3166 aa)

Predicted Functional Partners:

N307_02657

0.867

N307_10624

0.857

N307_05421

0.856

N307_11360

0.856

N307_00574

0.855

N307_04337

0.854

N307_07571

0.852

N307_09663

0.851

N307_11616

0.851

N307_00808

0.848

Your Current Organism:

Picoides pubescens

NCBI taxonomy Id: 118200
Other names: Dendrocopos pubescens, Downy woodpecker, Dryobates pubescens, P. pubescens

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N307_00574	N307_00808	A0A093G688	A0A093GJX9	Integrin beta.	Integrin alpha-9; Belongs to the integrin alpha chain family.	0.967
N307_00574	N307_02657	A0A093G688	A0A093GI30	Integrin beta.	Integrin alpha-11; Belongs to the integrin alpha chain family.	0.934
N307_00574	N307_04337	A0A093G688	A0A093FZQ5	Integrin beta.	Integrin beta; Belongs to the integrin beta chain family.	0.723
N307_00574	N307_05421	A0A093G688	A0A093FYH5	Integrin beta.	Integrin beta.	0.831
N307_00574	N307_05475	A0A093G688	A0A093GEJ3	Integrin beta.	Collagen alpha-3(VI) chain.	0.855
N307_00574	N307_07571	A0A093G688	A0A093GWH9	Integrin beta.	Integrin alpha-6; Belongs to the integrin alpha chain family.	0.972
N307_00574	N307_10624	A0A093G688	A0A093GKK5	Integrin beta.	Integrin alpha-1; Belongs to the integrin alpha chain family.	0.944
N307_00574	N307_11360	A0A093G688	A0A093IUD5	Integrin beta.	Integrin beta.	0.759
N307_00574	N307_11616	A0A093G688	A0A093J699	Integrin beta.	Integrin alpha-8; Belongs to the integrin alpha chain family.	0.961
N307_00808	N307_00574	A0A093GJX9	A0A093G688	Integrin alpha-9; Belongs to the integrin alpha chain family.	Integrin beta.	0.967
N307_00808	N307_02657	A0A093GJX9	A0A093GI30	Integrin alpha-9; Belongs to the integrin alpha chain family.	Integrin alpha-11; Belongs to the integrin alpha chain family.	0.708
N307_00808	N307_04337	A0A093GJX9	A0A093FZQ5	Integrin alpha-9; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.955
N307_00808	N307_05421	A0A093GJX9	A0A093FYH5	Integrin alpha-9; Belongs to the integrin alpha chain family.	Integrin beta.	0.953
N307_00808	N307_05475	A0A093GJX9	A0A093GEJ3	Integrin alpha-9; Belongs to the integrin alpha chain family.	Collagen alpha-3(VI) chain.	0.848
N307_00808	N307_07571	A0A093GJX9	A0A093GWH9	Integrin alpha-9; Belongs to the integrin alpha chain family.	Integrin alpha-6; Belongs to the integrin alpha chain family.	0.726
N307_00808	N307_09663	A0A093GJX9	A0A093GQQ5	Integrin alpha-9; Belongs to the integrin alpha chain family.	CD44 antigen.	0.467
N307_00808	N307_10624	A0A093GJX9	A0A093GKK5	Integrin alpha-9; Belongs to the integrin alpha chain family.	Integrin alpha-1; Belongs to the integrin alpha chain family.	0.672
N307_00808	N307_11360	A0A093GJX9	A0A093IUD5	Integrin alpha-9; Belongs to the integrin alpha chain family.	Integrin beta.	0.953
N307_00808	N307_11616	A0A093GJX9	A0A093J699	Integrin alpha-9; Belongs to the integrin alpha chain family.	Integrin alpha-8; Belongs to the integrin alpha chain family.	0.906
N307_02657	N307_00574	A0A093GI30	A0A093G688	Integrin alpha-11; Belongs to the integrin alpha chain family.	Integrin beta.	0.934

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.86

expected number of edges:

20

PPI enrichment p-value:

3.12e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050853

B cell receptor signaling pathway

5 of 32

2.44

3.84

3.26e-08

GO:0002768

Immune response-regulating cell surface receptor signaling pathway

7 of 132

1.97

3.66

3.03e-09

GO:0002429

Immune response-activating cell surface receptor signaling pathway

6 of 116

1.96

3.18

6.92e-08

GO:0042119

Neutrophil activation

3 of 21

2.4

1.98

0.00019

GO:0035335

Peptidyl-tyrosine dephosphorylation

3 of 28

2.27

1.83

0.00034

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004726

Non-membrane spanning protein tyrosine phosphatase activity

3 of 12

2.64

2.28

6.24e-05

GO:0001784

Phosphotyrosine residue binding

4 of 45

2.19

2.27

3.57e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019815

B cell receptor complex

3 of 4

3.12

2.83

7.38e-06

GO:0098802

Plasma membrane signaling receptor complex

4 of 137

1.71

1.54

0.00044

GO:0042101

T cell receptor complex

2 of 10

2.55

1.21

0.0060

GO:0009986

Cell surface

5 of 604

1.16

0.85

0.0046

GO:0098552

Side of membrane

4 of 441

1.2

0.72

0.0177

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14938

Mixed, incl. Generation of second messenger molecules, and FCERI mediated Ca+2 mobilization

8 of 99

2.15

5.35

4.76e-13

CL:14939

Mixed, incl. Generation of second messenger molecules, and FCERI mediated Ca+2 mobilization

7 of 93

2.12

4.7

2.25e-11

CL:14940

Mixed, incl. Generation of second messenger molecules, and Non-membrane spanning protein tyrosine kinase activity

4 of 65

2.03

2.19

3.48e-05

CL:15069

Mixed, incl. Signal regulatory protein family interactions, and Immunoglobulin complex

3 of 28

2.27

1.8

0.00038

CL:14941

Mixed, incl. Non-membrane spanning protein tyrosine kinase activity, and Generation of second messenger molecules

3 of 49

2.03

1.44

0.0016

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

oro04650

Natural killer cell mediated cytotoxicity

7 of 98

2.1

4.74

1.22e-11

oro04662

B cell receptor signaling pathway

5 of 71

2.09

3.38

6.17e-08

oro04380

Osteoclast differentiation

4 of 119

1.77

1.92

5.49e-05

oro04072

Phospholipase D signaling pathway

4 of 150

1.67

1.74

0.00010

oro05140

Leishmaniasis

3 of 75

1.85

1.54

0.00068

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-983695

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

5 of 36

2.39

3.84

2.59e-08

MAP-5690714

CD22 mediated BCR regulation

3 of 7

2.88

2.94

3.99e-06

MAP-114604

GPVI-mediated activation cascade

4 of 44

2.2

2.74

3.48e-06

MAP-512988

Interleukin-3, Interleukin-5 and GM-CSF signaling

4 of 53

2.12

2.63

4.69e-06

MAP-391160

Signal regulatory protein family interactions

3 of 15

2.55

2.53

1.89e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0019814

Immunoglobulin complex

5 of 26

2.53

4.24

6.34e-09

GOCC:0019815

B cell receptor complex

3 of 9

2.77

2.48

2.75e-05

GOCC:1904096

Protein tyrosine phosphatase complex

2 of 3

3.07

1.52

0.0018

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0727

SH2 domain

4 of 107

1.82

1.83

0.00012

KW-0904

Protein phosphatase

3 of 65

1.91

1.46

0.0012

KW-0675

Receptor

7 of 1693

0.86

0.7

0.0012

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR012152

Protein-tyrosine phosphatase, non-receptor type-6, -11

2 of 2

3.24

1.1

0.0107

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00252

Src homology 2 domains

4 of 111

1.8

1.66

0.00031

SM00194

Protein tyrosine phosphatase, catalytic domain

3 of 40

2.12

1.64

0.00068

SM00077

Immunoreceptor tyrosine-based activation motif

2 of 7

2.7

1.39

0.0029

SM00409

Immunoglobulin

4 of 306

1.36

1.0

0.0040

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