N307_03223 protein (Picoides pubescens) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

N307_03223

Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (460 aa)

Predicted Functional Partners:

N307_03381

0.836

N307_03043

0.809

N307_14070

0.685

N307_10662

0.620

N307_13632

0.609

N307_04872

0.597

N307_01911

0.574

N307_13079

0.558

N307_10553

0.525

N307_03731

0.525

Your Current Organism:

Picoides pubescens

NCBI taxonomy Id: 118200
Other names: Dendrocopos pubescens, Downy woodpecker, Dryobates pubescens, P. pubescens

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N307_01911	N307_03223	A0A093GLG0	A0A093GHR1	Ras-related protein Rab-2A.	Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.574
N307_01911	N307_03381	A0A093GLG0	A0A093H5Z5	Ras-related protein Rab-2A.	Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.842
N307_01911	N307_04872	A0A093GLG0	A0A093J393	Ras-related protein Rab-2A.	Ras-related protein Rab-14.	0.886
N307_03043	N307_03223	A0A093H2F2	A0A093GHR1	Cytochrome b5 reductase 4.	Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.809
N307_03043	N307_03381	A0A093H2F2	A0A093H5Z5	Cytochrome b5 reductase 4.	Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.809
N307_03043	N307_03731	A0A093H2F2	A0A093H943	Cytochrome b5 reductase 4.	Solute carrier family 22 member 2.	0.434
N307_03043	N307_10662	A0A093H2F2	A0A093IJ00	Cytochrome b5 reductase 4.	Glyceraldehyde-3-phosphate dehydrogenase.	0.621
N307_03043	N307_13632	A0A093H2F2	A0A093GX29	Cytochrome b5 reductase 4.	Bifunctional epoxide hydrolase 2.	0.789
N307_03223	N307_01911	A0A093GHR1	A0A093GLG0	Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	Ras-related protein Rab-2A.	0.574
N307_03223	N307_03043	A0A093GHR1	A0A093H2F2	Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	Cytochrome b5 reductase 4.	0.809
N307_03223	N307_03381	A0A093GHR1	A0A093H5Z5	Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.836
N307_03223	N307_03731	A0A093GHR1	A0A093H943	Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	Solute carrier family 22 member 2.	0.525
N307_03223	N307_04872	A0A093GHR1	A0A093J393	Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	Ras-related protein Rab-14.	0.597
N307_03223	N307_10553	A0A093GHR1	A0A093G167	Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	Solute carrier family 15 member 1.	0.525
N307_03223	N307_10662	A0A093GHR1	A0A093IJ00	Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.620
N307_03223	N307_13079	A0A093GHR1	A0A093IF81	Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	Tether containing UBX domain for GLUT4.	0.558
N307_03223	N307_13632	A0A093GHR1	A0A093GX29	Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	Bifunctional epoxide hydrolase 2.	0.609
N307_03223	N307_14070	A0A093GHR1	A0A093G8Z4	Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	Hepatocyte nuclear factor 1-alpha.	0.685
N307_03381	N307_01911	A0A093H5Z5	A0A093GLG0	Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	Ras-related protein Rab-2A.	0.842
N307_03381	N307_03043	A0A093H5Z5	A0A093H2F2	Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	Cytochrome b5 reductase 4.	0.809

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Network Stats

number of nodes:

11

number of edges:

11

average node degree:

2

avg. local clustering coefficient:

0.911

expected number of edges:

10

PPI enrichment p-value:

0.459

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032981

Mitochondrial respiratory chain complex I assembly

7 of 49

2.34

5.28

9.25e-12

GO:0042775

Mitochondrial ATP synthesis coupled electron transport

6 of 51

2.25

4.28

1.21e-09

GO:0006120

Mitochondrial electron transport, NADH to ubiquinone

5 of 23

2.52

4.27

5.27e-09

GO:0072593

Reactive oxygen species metabolic process

3 of 60

1.88

1.21

0.0041

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008137

NADH dehydrogenase (ubiquinone) activity

5 of 33

2.36

3.67

5.53e-08

GO:0016491

Oxidoreductase activity

6 of 654

1.15

1.06

0.00038

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005747

Mitochondrial respiratory chain complex I

6 of 41

2.35

4.73

2.11e-10

GO:0005743

Mitochondrial inner membrane

8 of 349

1.54

2.74

8.05e-10

GO:0031966

Mitochondrial membrane

9 of 512

1.43

2.45

3.46e-10

GO:0005739

Mitochondrion

11 of 1214

1.14

1.64

2.11e-10

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33435522

(2021) Mitochondrial Structure and Bioenergetics in Normal and Disease Conditions.

10 of 105

2.16

6.48

1.88e-16

PMID:27226634

(2016) NDUFAF5 Hydroxylates NDUFS7 at an Early Stage in the Assembly of Human Complex I.

5 of 31

2.39

3.13

8.76e-07

PMID:24089531

(2013) NDUFAF7 methylates arginine 85 in the NDUFS2 subunit of human complex I.

5 of 31

2.39

3.13

8.76e-07

PMID:33882309

(2021) NDUFS3 depletion permits complex I maturation and reveals TMEM126AOPA7 as an assembly factor binding the ND4-module intermediate.

5 of 40

2.28

2.97

1.42e-06

PMID:27743346

(2016) Amazing structure of respirasome: unveiling the secrets of cell respiration.

4 of 23

2.42

2.33

3.92e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1916

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., and Proton motive force-driven ATP synthesis

11 of 115

2.16

7.7

1.04e-20

CL:2120

Complex I biogenesis

5 of 7

3.04

5.73

2.50e-11

CL:1930

NADH dehydrogenase complex

6 of 37

2.39

5.03

5.69e-11

CL:1932

NADH dehydrogenase complex

4 of 29

2.32

3.01

1.28e-06

CL:1975

Mitochondrial electron transport, NADH to ubiquinone

2 of 5

2.79

1.44

0.0024

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gga00190

Oxidative phosphorylation

6 of 110

1.92

3.44

7.12e-09

gga01100

Metabolic pathways

6 of 1204

0.88

0.66

0.0039

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

GGA-6799198

Complex I biogenesis

11 of 51

2.52

10.8

1.08e-24

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005743

Mitochondrial inner membrane

7 of 192

1.75

3.07

7.38e-09

GOCC:0070469

Respirasome

4 of 63

1.99

2.32

1.47e-05

GOCC:0005747

Mitochondrial respiratory chain complex I

3 of 22

2.32

2.14

8.35e-05

GOCC:0005739

Mitochondrion

10 of 789

1.29

1.99

9.36e-10

GOCC:1902495

Transmembrane transporter complex

3 of 158

1.46

0.89

0.0112

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0679

Respiratory chain

3 of 23

2.3

1.92

0.00023

KW-1278

Translocase

3 of 37

2.09

1.73

0.00043

KW-0830

Ubiquinone

2 of 9

2.53

1.49

0.0018

KW-0520

NAD

3 of 73

1.8

1.37

0.0015

KW-0496

Mitochondrion

3 of 207

1.34

0.75

0.0209

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