N307_12595 protein (Picoides pubescens) - STRING interaction network

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second shell of interactors

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Known Interactions

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Predicted Interactions

gene neighborhood

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gene co-occurrence

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Score

N307_12595

Putative low affinity copper uptake protein 2. (84 aa)

Predicted Functional Partners:

N307_10208

0.589

N307_14395

0.589

N307_10147

0.574

N307_14531

0.566

N307_01203

0.565

N307_14792

0.555

N307_04390

0.554

N307_05679

0.548

N307_13004

0.524

N307_07161

0.518

Your Current Organism:

Picoides pubescens

NCBI taxonomy Id: 118200
Other names: Dendrocopos pubescens, Downy woodpecker, Dryobates pubescens, P. pubescens

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N307_01203	N307_12595	A0A093GLX6	A0A093GTK9	26S proteasome non-ATPase regulatory subunit 4.	Putative low affinity copper uptake protein 2.	0.565
N307_04390	N307_05679	A0A093G2U9	A0A093G854	Natural resistance-associated macrophage protein 1.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.414
N307_04390	N307_10208	A0A093G2U9	A0A093GDT5	Natural resistance-associated macrophage protein 1.	Copper-transporting ATPase 1.	0.564
N307_04390	N307_12595	A0A093G2U9	A0A093GTK9	Natural resistance-associated macrophage protein 1.	Putative low affinity copper uptake protein 2.	0.554
N307_04390	N307_13004	A0A093G2U9	A0A093GEW6	Natural resistance-associated macrophage protein 1.	Zinc transporter ZIP11.	0.461
N307_04390	N307_14395	A0A093G2U9	A0A093GVJ6	Natural resistance-associated macrophage protein 1.	Copper-transporting ATPase 2.	0.564
N307_04390	N307_14531	A0A093G2U9	A0A093GHI5	Natural resistance-associated macrophage protein 1.	Zinc transporter ZIP3.	0.569
N307_05679	N307_04390	A0A093G854	A0A093G2U9	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	Natural resistance-associated macrophage protein 1.	0.414
N307_05679	N307_10147	A0A093G854	A0A093FTW6	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	Copper transport protein ATOX1.	0.428
N307_05679	N307_12595	A0A093G854	A0A093GTK9	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	Putative low affinity copper uptake protein 2.	0.548
N307_05679	N307_14531	A0A093G854	A0A093GHI5	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	Zinc transporter ZIP3.	0.511
N307_07161	N307_10147	A0A093GA78	A0A093FTW6	Uncharacterized protein.	Copper transport protein ATOX1.	0.574
N307_07161	N307_10208	A0A093GA78	A0A093GDT5	Uncharacterized protein.	Copper-transporting ATPase 1.	0.437
N307_07161	N307_12595	A0A093GA78	A0A093GTK9	Uncharacterized protein.	Putative low affinity copper uptake protein 2.	0.518
N307_07161	N307_14395	A0A093GA78	A0A093GVJ6	Uncharacterized protein.	Copper-transporting ATPase 2.	0.437
N307_07161	N307_14792	A0A093GA78	A0A093GG64	Uncharacterized protein.	Uncharacterized protein.	0.880
N307_10147	N307_05679	A0A093FTW6	A0A093G854	Copper transport protein ATOX1.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.428
N307_10147	N307_07161	A0A093FTW6	A0A093GA78	Copper transport protein ATOX1.	Uncharacterized protein.	0.574
N307_10147	N307_10208	A0A093FTW6	A0A093GDT5	Copper transport protein ATOX1.	Copper-transporting ATPase 1.	0.975
N307_10147	N307_12595	A0A093FTW6	A0A093GTK9	Copper transport protein ATOX1.	Putative low affinity copper uptake protein 2.	0.574

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.881

expected number of edges:

15

PPI enrichment p-value:

6.79e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051276

Chromosome organization

5 of 26

1.86

2.37

5.40e-06

GO:0071103

DNA conformation change

4 of 17

1.95

2.05

5.67e-05

GO:0006281

DNA repair

5 of 51

1.57

1.72

5.67e-05

GO:0006259

DNA metabolic process

8 of 178

1.23

1.49

3.02e-06

GO:0006260

DNA replication

3 of 36

1.5

0.95

0.0083

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008094

ATP-dependent activity, acting on DNA

6 of 21

2.03

3.7

4.95e-09

GO:0140097

Catalytic activity, acting on DNA

10 of 107

1.55

3.13

1.83e-12

GO:0003678

DNA helicase activity

3 of 8

2.15

1.85

0.00025

GO:0003887

DNA-directed DNA polymerase activity

3 of 11

2.01

1.67

0.00049

GO:0140664

ATP-dependent DNA damage sensor activity

2 of 4

2.27

1.21

0.0057

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009360

DNA polymerase III complex

2 of 5

2.18

0.95

0.0170

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:599

Mixed, incl. Mismatched DNA binding, and DNA helicase activity

6 of 7

2.51

5.44

1.54e-11

CL:595

DNA repair, and Primosome

8 of 25

2.08

5.21

3.03e-13

CL:596

DNA repair, and DNA helicase activity

7 of 18

2.16

5.0

6.03e-12

CL:593

DNA repair, and DNA-directed DNA polymerase activity

9 of 41

1.92

4.75

1.32e-13

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03430

Mismatch repair

6 of 27

1.92

3.41

9.30e-09

map03440

Homologous recombination

5 of 30

1.8

2.56

9.32e-07

map03420

Nucleotide excision repair

3 of 13

1.94

1.72

0.00033

map03030

DNA replication

3 of 35

1.51

1.09

0.0037

map03410

Base excision repair

2 of 22

1.53

0.67

0.0449

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0033202

DNA helicase complex

3 of 5

2.35

1.91

0.00025

GOCC:0044815

DNA packaging complex

3 of 11

2.01

1.65

0.00053

GOCC:0009360

DNA polymerase III complex

2 of 6

2.1

0.98

0.0142

GOCC:1902494

Catalytic complex

5 of 245

0.88

0.58

0.0142

GOCC:0005622

Intracellular

10 of 1593

0.37

0.28

0.0241

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0347

Helicase

3 of 12

1.97

1.45

0.0014

KW-0234

DNA repair

3 of 28

1.6

1.1

0.0044

KW-0548

Nucleotidyltransferase

3 of 32

1.55

1.08

0.0044

KW-0239

DNA-directed DNA polymerase

2 of 8

1.97

1.04

0.0104

KW-0238

DNA-binding

6 of 209

1.03

0.85

0.0014

(more ...)

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