N307_08328 protein (Picoides pubescens) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

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[Homology]

Score

N307_08328

Histamine H1 receptor; Belongs to the G-protein coupled receptor 1 family. (450 aa)

Predicted Functional Partners:

N307_05297

0.880

N307_14489

0.858

N307_08382

0.858

N307_00631

0.821

N307_12279

0.794

N307_00364

0.791

N307_08889

0.787

N307_07660

0.787

N307_08613

0.787

N307_11697

0.787

Your Current Organism:

Picoides pubescens

NCBI taxonomy Id: 118200
Other names: Dendrocopos pubescens, Downy woodpecker, Dryobates pubescens, P. pubescens

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N307_00364	N307_00631	A0A093GJY7	A0A093GNM4	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit beta-5.	0.889
N307_00364	N307_05297	A0A093GJY7	A0A093GRL1	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit beta-4.	0.975
N307_00364	N307_07660	A0A093GJY7	A0A093G3M6	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13.	0.922
N307_00364	N307_08328	A0A093GJY7	A0A093IWZ3	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Histamine H1 receptor; Belongs to the G-protein coupled receptor 1 family.	0.791
N307_00364	N307_08382	A0A093GJY7	A0A093I4H2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit alpha-11.	0.882
N307_00364	N307_08613	A0A093GJY7	A0A093GJY1	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5.	0.712
N307_00364	N307_08889	A0A093GJY7	A0A093FW95	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11.	0.896
N307_00364	N307_11697	A0A093GJY7	A0A093JBY3	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.896
N307_00364	N307_12279	A0A093GJY7	A0A093IPF2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10.	0.762
N307_00364	N307_14489	A0A093GJY7	A0A093GDL7	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein G(Q) subunit alpha.	0.882
N307_00631	N307_00364	A0A093GNM4	A0A093GJY7	Guanine nucleotide-binding protein subunit beta-5.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.889
N307_00631	N307_05297	A0A093GNM4	A0A093GRL1	Guanine nucleotide-binding protein subunit beta-5.	Guanine nucleotide-binding protein subunit beta-4.	0.849
N307_00631	N307_07660	A0A093GNM4	A0A093G3M6	Guanine nucleotide-binding protein subunit beta-5.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13.	0.888
N307_00631	N307_08328	A0A093GNM4	A0A093IWZ3	Guanine nucleotide-binding protein subunit beta-5.	Histamine H1 receptor; Belongs to the G-protein coupled receptor 1 family.	0.821
N307_00631	N307_08382	A0A093GNM4	A0A093I4H2	Guanine nucleotide-binding protein subunit beta-5.	Guanine nucleotide-binding protein subunit alpha-11.	0.895
N307_00631	N307_08613	A0A093GNM4	A0A093GJY1	Guanine nucleotide-binding protein subunit beta-5.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5.	0.980
N307_00631	N307_08889	A0A093GNM4	A0A093FW95	Guanine nucleotide-binding protein subunit beta-5.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11.	0.937
N307_00631	N307_11697	A0A093GNM4	A0A093JBY3	Guanine nucleotide-binding protein subunit beta-5.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.982
N307_00631	N307_12279	A0A093GNM4	A0A093IPF2	Guanine nucleotide-binding protein subunit beta-5.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10.	0.935
N307_00631	N307_14489	A0A093GNM4	A0A093GDL7	Guanine nucleotide-binding protein subunit beta-5.	Guanine nucleotide-binding protein G(Q) subunit alpha.	0.895

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.813

expected number of edges:

28

PPI enrichment p-value:

0.244

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006099

Tricarboxylic acid cycle

10 of 20

2.29

7.77

7.28e-19

GO:0006091

Generation of precursor metabolites and energy

11 of 119

1.56

3.51

3.27e-15

GO:0044238

Primary metabolic process

11 of 1488

0.46

0.37

0.0019

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000104

Succinate dehydrogenase activity

4 of 4

2.59

3.15

1.20e-06

GO:0036440

Citrate synthase activity

2 of 2

2.59

1.12

0.0090

GO:0008177

Succinate dehydrogenase (ubiquinone) activity

2 of 2

2.59

1.12

0.0090

GO:0004775

succinate-CoA ligase (ADP-forming) activity

2 of 2

2.59

1.12

0.0090

GO:0016417

S-acyltransferase activity

2 of 3

2.42

1.11

0.0090

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990204

Oxidoreductase complex

4 of 15

2.02

2.38

1.23e-05

GO:1902494

Catalytic complex

5 of 88

1.35

1.39

0.00012

GO:0045239

Tricarboxylic acid cycle enzyme complex

2 of 3

2.42

1.38

0.0028

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:23902230

(2013) Systems perspectives on erythromycin biosynthesis by comparative genomic and transcriptomic analyses of S. erythraea E3 and NRRL23338 strains.

3 of 18

1.82

1.84

0.00011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1985

Tricarboxylic acid cycle

8 of 11

2.46

7.28

4.74e-16

CL:1982

Citrate cycle (TCA cycle), and FAD-dependent oxidoreductase 2, FAD binding domain

9 of 24

2.17

6.5

1.93e-16

CL:1980

Mixed, incl. Citrate cycle (TCA cycle), and Pyruvate metabolism

11 of 51

1.93

5.87

1.90e-18

CL:1981

Citrate cycle (TCA cycle), and Pyruvate metabolism

10 of 42

1.97

5.77

6.68e-17

CL:1987

Succinate dehydrogenase activity

4 of 5

2.5

3.43

2.66e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00020

Citrate cycle (TCA cycle)

10 of 20

2.29

8.11

6.57e-20

map01200

Carbon metabolism

10 of 113

1.54

3.24

1.61e-13

map00190

Oxidative phosphorylation

4 of 39

1.61

1.74

6.77e-05

map00650

Butanoate metabolism

4 of 40

1.59

1.73

6.77e-05

map01120

Microbial metabolism in diverse environments

10 of 317

1.09

1.47

2.29e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045239

Tricarboxylic acid cycle enzyme complex

4 of 6

2.42

3.03

1.51e-06

GOCC:1990204

Oxidoreductase complex

5 of 28

1.85

2.56

1.51e-06

GOCC:0045273

Respiratory chain complex II

3 of 5

2.37

2.25

5.48e-05

GOCC:0045281

Succinate dehydrogenase complex

2 of 2

2.59

1.56

0.0014

GOCC:0045274

Plasma membrane respiratory chain complex II

2 of 2

2.59

1.56

0.0014

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0816

Tricarboxylic acid cycle

6 of 12

2.29

4.65

2.14e-10

KW-0450

Lipoyl

2 of 4

2.29

1.08

0.0102

KW-0012

Acyltransferase

3 of 54

1.34

0.72

0.0257

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01127

Succinate dehydrogenase/Fumarate reductase transmembrane subunit

2 of 2

2.59

0.91

0.0227

PF00549

CoA-ligase

2 of 2

2.59

0.91

0.0227

PF00285

Citrate synthase, C-terminal domain

2 of 2

2.59

0.91

0.0227

PF02817

e3 binding domain

2 of 3

2.42

0.9

0.0227

PF00198

2-oxoacid dehydrogenases acyltransferase (catalytic domain)

2 of 3

2.42

0.9

0.0227

(more ...)

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