STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
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[Homology]
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tilStRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. (272 aa)    
Predicted Functional Partners:
hprT
Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
 
 0.984
thiS
Thiamine biosynthesis protein ThiS.
  
 
 0.873
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 
 0.870
GAB98382.1
Hypothetical protein.
     
 0.859
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.796
gltB
Glutamate synthase large subunit.
    
  0.795
tadA
tRNA-specific adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
 
 0.779
mfd
Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
 
  
 0.747
GAB97327.1
IMP dehydrogenase family protein.
  
 
  0.732
lysX
Phosphatidylglycerol lysyltransferase/lysine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family.
   
 
 0.706
Your Current Organism:
Kineosphaera limosa
NCBI taxonomy Id: 1184609
Other names: K. limosa NBRC 100340, Kineosphaera limosa Lpha5, Kineosphaera limosa NBRC 100340, Kineosphaera limosa str. NBRC 100340, Kineosphaera limosa strain NBRC 100340, [uncultured] High G+C Gram-positive bacterium Lpha5
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