STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SOSTSclerostin. (212 aa)    
Predicted Functional Partners:
LRP6
Low-density lipoprotein receptor-related protein 6 isoform X1.
    
 0.999
LRP5
Low-density lipoprotein receptor-related protein 5.
    
 0.998
PTH
Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family.
      
 0.832
MEPE
Matrix extracellular phosphoglycoprotein isoform X1.
      
 0.778
FGF23
Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.
      
 0.778
DKK1
Dickkopf-related protein 1.
      
 0.713
RUNX2
Runt-related transcription factor 2 isoform X1.
      
 0.686
BGLAP
Osteocalcin; Binds strongly to apatite and calcium.
      
 0.685
VRK3
Inactive serine/threonine-protein kinase VRK3.
    
 0.648
CTNNB1
Catenin beta-1 isoform X1.
   
 
 0.645
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.