ALK protein (Lipotes vexillifer) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

ALK

Tyrosine-protein kinase receptor. (1619 aa)

Predicted Functional Partners:

EML4

0.982

PIK3CA

0.976

PTN

0.975

KRAS

0.973

NRAS

0.968

MDK

0.962

HRAS

0.952

JAK2

0.950

PLCG1

0.949

PIK3R1

0.948

Your Current Organism:

Lipotes vexillifer

NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALK	EML4	A0A340YD63	A0A340WBD1	Tyrosine-protein kinase receptor.	Echinoderm microtubule-associated protein-like 4 isoform X2.	0.982
ALK	HRAS	A0A340YD63	A0A340Y3B4	Tyrosine-protein kinase receptor.	GTPase HRas isoform X1.	0.952
ALK	JAK2	A0A340YD63	A0A340WTZ3	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase.	0.950
ALK	KRAS	A0A340YD63	A0A340WCQ7	Tyrosine-protein kinase receptor.	GTPase KRas.	0.973
ALK	MDK	A0A340YD63	A0A340X754	Tyrosine-protein kinase receptor.	Midkine isoform X1.	0.962
ALK	NRAS	A0A340YD63	A0A340XT90	Tyrosine-protein kinase receptor.	GTPase NRas.	0.968
ALK	PIK3CA	A0A340YD63	A0A340Y0D6	Tyrosine-protein kinase receptor.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family.	0.976
ALK	PIK3R1	A0A340YD63	A0A340X6G2	Tyrosine-protein kinase receptor.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.948
ALK	PLCG1	A0A340YD63	A0A340XU67	Tyrosine-protein kinase receptor.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.949
ALK	PTN	A0A340YD63	A0A340XZZ0	Tyrosine-protein kinase receptor.	Pleiotrophin isoform X1.	0.975
EML4	ALK	A0A340WBD1	A0A340YD63	Echinoderm microtubule-associated protein-like 4 isoform X2.	Tyrosine-protein kinase receptor.	0.982
EML4	HRAS	A0A340WBD1	A0A340Y3B4	Echinoderm microtubule-associated protein-like 4 isoform X2.	GTPase HRas isoform X1.	0.920
EML4	JAK2	A0A340WBD1	A0A340WTZ3	Echinoderm microtubule-associated protein-like 4 isoform X2.	Tyrosine-protein kinase.	0.915
EML4	KRAS	A0A340WBD1	A0A340WCQ7	Echinoderm microtubule-associated protein-like 4 isoform X2.	GTPase KRas.	0.963
EML4	NRAS	A0A340WBD1	A0A340XT90	Echinoderm microtubule-associated protein-like 4 isoform X2.	GTPase NRas.	0.930
EML4	PIK3CA	A0A340WBD1	A0A340Y0D6	Echinoderm microtubule-associated protein-like 4 isoform X2.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family.	0.942
EML4	PIK3R1	A0A340WBD1	A0A340X6G2	Echinoderm microtubule-associated protein-like 4 isoform X2.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.916
EML4	PLCG1	A0A340WBD1	A0A340XU67	Echinoderm microtubule-associated protein-like 4 isoform X2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.915
HRAS	ALK	A0A340Y3B4	A0A340YD63	GTPase HRas isoform X1.	Tyrosine-protein kinase receptor.	0.952
HRAS	EML4	A0A340Y3B4	A0A340WBD1	GTPase HRas isoform X1.	Echinoderm microtubule-associated protein-like 4 isoform X2.	0.920