STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
menHPropable alpha/beta hydrolase fold protein; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC); Belongs to the AB hydrolase superfamily. MenH family. (269 aa)    
Predicted Functional Partners:
menD
2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily.
 
 0.991
EKF01144.1
AMP-binding enzyme; KEGG: npu:Npun_F2181 0. amino acid adenylation domain-containing protein.
   
 0.937
EKE97447.1
AMP-binding enzyme; KEGG: ava:Ava_1613 0. non-ribosomal peptide synthase.
  
 0.933
EKF01032.1
Hypothetical protein; KEGG: bcz:BCZK2789 0.00051 prpA; serine/threonine protein phosphatase K01090.
    
  0.912
menC
O-succinylbenzoic acid synthetase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
 
  
  0.904
EKF04555.1
AMP-binding enzyme; KEGG: ava:Ava_C0009 0. amino acid adenylation; Psort location: CytoplasmicMembrane, score: 8.46.
   
 0.879
EKE99930.1
Hypothetical protein; KEGG: npu:Npun_R3452 0. AMP-dependent synthetase and ligase; Psort location: CytoplasmicMembrane, score: 8.46.
   
 0.879
EKE96453.1
KEGG: npu:Npun_F3359 5.4e-233 beta-ketoacyl synthase; Psort location: CytoplasmicMembrane, score: 9.82.
  
 0.844
EKF03198.1
KEGG: eta:ETA_13580 4.0e-109 8-amino-7-oxononanoate synthase K00639; Psort location: Cytoplasmic, score: 8.96.
  
 0.817
menB
Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA).
 
  
 0.779
Your Current Organism:
Tolypothrix sp. PCC7601
NCBI taxonomy Id: 1188
Other names: Calothrix sp. PCC 7601, Fremyella diplosiphon ACMM 396, Fremyella diplosiphon IAM M-100, Fremyella diplosiphon UTEX B 481, Microchaete diplosiphon UTEX B 481, T. sp. PCC 7601, Tolypothrix (Calothrix) sp. PCC 7601, Tolypothrix sp. PCC 7601, Tolypothrix sp. PCC 7601 = UTEX B 481
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