STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
kaiCCircadian clock protein KaiC; Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction; Belongs to the KaiC family. (520 aa)    
Predicted Functional Partners:
kaiB
Circadian clock protein KaiB; Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead needs the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC; Belongs to the KaiB family.
 
 
 
 0.997
EKF04680.1
Cyanobacterial circadian clock protein; Component of the kaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The kaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of kaiC. In contrast, the presence of kaiB in the complex decreases the phosphorylation status of kaiC, suggesting that kaiB acts by antagonizing the interaction between kaiA and kaiC. A kaiA dimer is sufficient to enhan [...]
 
 
 
 0.990
EKF05442.1
KaiB domain protein; KEGG: cyc:PCC7424_5063 0.0055 adaptive-response sensory kinase K08479; Psort location: Cytoplasmic, score: 9.26.
 
 
 
 0.981
sasA
Putative sensor histidine kinase; May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs.
  
 
 
 0.828
EKF06268.1
Sensor histidine kinase; KEGG: ava:Ava_4701 1.4e-173 multi-sensor hybrid histidine kinase K00936; Psort location: CytoplasmicMembrane, score: 9.99.
   
 
 0.715
EKF00588.1
Sensor histidine kinase; KEGG: ava:Ava_4701 2.8e-153 multi-sensor hybrid histidine kinase K00936; Psort location: CytoplasmicMembrane, score: 10.00.
   
 
 0.715
EKF03822.1
Sensor histidine kinase; KEGG: ava:Ava_1559 4.2e-153 PAS/PAC sensor signal transduction histidine kinase K00936; Psort location: CytoplasmicMembrane, score: 7.88.
 
 
 
 0.704
EKF01338.1
Sensor histidine kinase; KEGG: npu:Npun_R3691 0. multi-sensor hybrid histidine kinase; Psort location: CytoplasmicMembrane, score: 10.00.
   
 
 0.703
EKF05374.1
Putative sensor histidine kinase; KEGG: cyc:PCC7424_1976 8.8e-53 multi-sensor signal transduction histidine kinase.
 
 
 
 0.689
EKF01595.1
Sensor histidine kinase; KEGG: ana:all2875 3.7e-177 two-component hybrid sensor and regulator; K02489 two-component system, PleD related family, sensor kinase and response regulator; Psort location: CytoplasmicMembrane, score: 9.99.
   
 
 0.685
Your Current Organism:
Tolypothrix sp. PCC7601
NCBI taxonomy Id: 1188
Other names: Calothrix sp. PCC 7601, Fremyella diplosiphon ACMM 396, Fremyella diplosiphon IAM M-100, Fremyella diplosiphon UTEX B 481, Microchaete diplosiphon UTEX B 481, T. sp. PCC 7601, Tolypothrix (Calothrix) sp. PCC 7601, Tolypothrix sp. PCC 7601, Tolypothrix sp. PCC 7601 = UTEX B 481
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.