STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
EKF04740.1Heat shock protein 70 DnaK; KEGG: pmo:Pmob_1649 1.9e-20 dnaK; molecular chaperone DnaK K04043; Belongs to the heat shock protein 70 family. (532 aa)    
Predicted Functional Partners:
EKF01713.1
Hypothetical protein; KEGG: mrd:Mrad2831_3544 0.0038 ribulose-phosphate 3-epimerase K03687.
 
 0.985
grpE
Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...]
 
 0.975
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 0.969
EKE99383.1
Chaperone protein DnaJ; KEGG: dme:Dmel_CG7130 1.1e-13 CG7130 gene product from transcript CG7130-RA; K01509 adenosinetriphosphatase; Psort location: Cytoplasmic, score: 9.97.
  
 0.969
EKE97499.1
Heat shock protein DnaJ; KEGG: dme:Dmel_CG7130 3.5e-07 CG7130 gene product from transcript CG7130-RA; K01509 adenosinetriphosphatase; Psort location: CytoplasmicMembrane, score: 9.82.
  
 0.968
EKE97140.1
Chaperone HtpG; KEGG: eci:UTI89_C0501 6.3e-63 htpG; heat shock protein 90 K04079.
   
 0.965
EKE99246.1
Heat shock protein DnaJ; KEGG: dme:Dmel_CG7130 1.4e-13 CG7130 gene product from transcript CG7130-RA; K01509 adenosinetriphosphatase; Psort location: Cytoplasmic, score: 9.94.
  
 0.958
groL
Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 0.942
groS
Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
  
 
 0.929
EKE98545.1
DnaJ domain protein; KEGG: dme:Dmel_CG7130 2.2e-08 CG7130 gene product from transcript CG7130-RA; K01509 adenosinetriphosphatase; Psort location: Cytoplasmic, score: 8.96.
  
 0.926
Your Current Organism:
Tolypothrix sp. PCC7601
NCBI taxonomy Id: 1188
Other names: Calothrix sp. PCC 7601, Fremyella diplosiphon ACMM 396, Fremyella diplosiphon IAM M-100, Fremyella diplosiphon UTEX B 481, Microchaete diplosiphon UTEX B 481, T. sp. PCC 7601, Tolypothrix (Calothrix) sp. PCC 7601, Tolypothrix sp. PCC 7601, Tolypothrix sp. PCC 7601 = UTEX B 481
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.