STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EKF05201.1NUDIX family hydrolase; KEGG: npu:Npun_R5795 2.4e-54 mutator MutT protein; K03574 7,8-dihydro-8-oxoguanine triphosphatase. (143 aa)    
Predicted Functional Partners:
mutM
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
 
   
 0.563
gshB
Glutathione synthase; KEGG: npu:Npun_F4803 1.2e-146 glutathione synthetase K01920; Belongs to the prokaryotic GSH synthase family.
  
   
 0.499
polA
DNA-directed DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
   
 0.480
EKF05200.1
Hypothetical protein; KEGG: dra:DR_0071 0.88 peptidyl-prolyl cis-trans isomerase; K03769 peptidyl-prolyl cis-trans isomerase C.
       0.441
EKF05202.1
Putative cystathionine beta-synthase; KEGG: npu:Npun_R5794 5.8e-69 signal transduction protein.
       0.435
EKE99431.1
Recombination protein J; KEGG: ana:all1989 0. recJ; single-strand-DNA-specific exonuclease; K07462 single-stranded-DNA-specific exonuclease; Psort location: Cytoplasmic, score: 8.96.
  
  
 0.401
Your Current Organism:
Tolypothrix sp. PCC7601
NCBI taxonomy Id: 1188
Other names: Calothrix sp. PCC 7601, Fremyella diplosiphon ACMM 396, Fremyella diplosiphon IAM M-100, Fremyella diplosiphon UTEX B 481, Microchaete diplosiphon UTEX B 481, T. sp. PCC 7601, Tolypothrix (Calothrix) sp. PCC 7601, Tolypothrix sp. PCC 7601, Tolypothrix sp. PCC 7601 = UTEX B 481
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