Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
polADNA-directed DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (974 aa)    
Predicted Functional Partners:
EKF02734.1
DNA-directed DNA polymerase; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of repl [...]
 
 0.994
EKE97885.1
KEGG: ava:Ava_C0075 2.0e-226 DNA polymerase III beta subunit family protein K02338; Psort location: Cytoplasmic, score: 9.97.
 
 0.993
EKE97888.1
KEGG: pab:PAB1128 1.3e-21 polI; DNA polymerase I; K02319 DNA polymerase I; Psort location: Cytoplasmic, score: 8.96.
   
 0.989
recA
Recombination protein A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 0.988
EKE97700.1
KEGG: npu:Npun_F6434 5.3e-130 DNA polymerase III, delta prime subunit K02341; Psort location: Cytoplasmic, score: 9.26.
  
 0.981
mutS
DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
  
 0.973
EKE96682.1
Hypothetical protein; KEGG: tma:TM0173 0.39 reverse gyrase K03170; Psort location: Cytoplasmic, score: 8.96.
   
 0.961
EKF00227.1
Putative Rad3 DNA helicase; KEGG: npu:Npun_F5207 8.0e-214 putative ATP-dependent DNA helicase DinG; K03722 ATP-dependent DNA helicase DinG; Psort location: CytoplasmicMembrane, score: 9.82.
   
 0.961
sbcD
DNA repair exonuclease SbcD; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
  
 0.960
EKF01112.1
ATP-dependent helicase RecQ; KEGG: npu:Npun_F0932 4.3e-215 ATP-dependent DNA helicase RecQ; K03654 ATP-dependent DNA helicase RecQ; Psort location: CytoplasmicMembrane, score: 8.46.
  
 0.956
Your Current Organism:
Tolypothrix sp. PCC7601
NCBI taxonomy Id: 1188
Other names: Calothrix sp. PCC 7601, Fremyella diplosiphon ACMM 396, Fremyella diplosiphon IAM M-100, Fremyella diplosiphon UTEX B 481, Microchaete diplosiphon UTEX B 481, T. sp. PCC 7601, Tolypothrix (Calothrix) sp. PCC 7601, Tolypothrix sp. PCC 7601, Tolypothrix sp. PCC 7601 = UTEX B 481
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.