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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (457 aa)    
Predicted Functional Partners:
EKF03631.1
KEGG: npu:Npun_F4464 2.1e-112 phosphomethylpyrimidine kinase.
 
 0.996
thiG
Glycine oxidase ThiO; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 0.993
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.970
EKF02081.1
Putative thiamine biosynthesis protein; KEGG: amu:Amuc_0148 0.25 saccharopine dehydrogenase; K00290 saccharopine dehydrogenase (NAD+, L-lysine forming).
  
  
 0.921
cofG
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.
  
  
 0.865
cofH
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine.
  
  
 0.865
EKF04701.1
KEGG: pmf:P9303_22891 2.5e-132 thiF; molybdopterin biosynthesis protein K03751; Psort location: Cytoplasmic, score: 9.97.
  
 0.847
purM
Phosphoribosylformylglycinamidine cyclo-ligase; KEGG: mar:MAE_44360 6.4e-125 purM; phosphoribosylaminoimidazole synthetase; K01933 phosphoribosylformylglycinamidine cyclo-ligase.
     
 0.814
purK
Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
     
  0.800
EKF04296.1
ThiF family protein; KEGG: fal:FRAAL6442 1.0e-46 hesA2; protein HesA; Psort location: Cytoplasmic, score: 9.26.
 
  
 0.779
Your Current Organism:
Tolypothrix sp. PCC7601
NCBI taxonomy Id: 1188
Other names: Calothrix sp. PCC 7601, Fremyella diplosiphon ACMM 396, Fremyella diplosiphon IAM M-100, Fremyella diplosiphon UTEX B 481, Microchaete diplosiphon UTEX B 481, T. sp. PCC 7601, Tolypothrix (Calothrix) sp. PCC 7601, Tolypothrix sp. PCC 7601, Tolypothrix sp. PCC 7601 = UTEX B 481
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