STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
menA1,4-dihydroxy-2-naphthoate phytyltransferase; Involved in the synthesis of phylloquinone (vitamin K1). Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4- naphthoquinone; Belongs to the MenA family. Type 2 subfamily. (298 aa)    
Predicted Functional Partners:
EKF03620.1
KEGG: ava:Ava_0810 7.3e-188 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885; Psort location: CytoplasmicMembrane, score: 7.88.
 
  
  0.919
menC
O-succinylbenzoic acid synthetase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
 
   
 0.878
EKF05011.1
KEGG: ana:alr0096 1.9e-148 sds; solanesyl diphosphate synthase; K02523 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family.
 
  
 0.873
menD
2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily.
 
   
 0.863
EKF03518.1
KEGG: npu:Npun_F6461 4.8e-200 isochorismate synthase K02552; Psort location: Cytoplasmic, score: 9.26.
 
   
 0.844
menB
Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA).
 
   
 0.826
EKF05631.1
KEGG: ava:Ava_1497 2.5e-210 geranylgeranyl reductase; K10960 geranylgeranyl reductase; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.815
EKF03517.1
Hypothetical protein; KEGG: tel:tll0054 0.9993 gmk; guanylate kinase K00942.
       0.752
menH
Propable alpha/beta hydrolase fold protein; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC); Belongs to the AB hydrolase superfamily. MenH family.
 
 
 
 0.603
EKF03512.1
Hypothetical protein; Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis; Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily.
 
   
 0.569
Your Current Organism:
Tolypothrix sp. PCC7601
NCBI taxonomy Id: 1188
Other names: Calothrix sp. PCC 7601, Fremyella diplosiphon ACMM 396, Fremyella diplosiphon IAM M-100, Fremyella diplosiphon UTEX B 481, Microchaete diplosiphon UTEX B 481, T. sp. PCC 7601, Tolypothrix (Calothrix) sp. PCC 7601, Tolypothrix sp. PCC 7601, Tolypothrix sp. PCC 7601 = UTEX B 481
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