STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EKF04133.1KEGG: npu:Npun_R1629 7.8e-97 uroporphyrinogen III synthase HEM4. (280 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.996
EKF03148.1
KEGG: npu:Npun_R1873 3.3e-114 uroporphyrin-III C-methyltransferase K02302; Belongs to the precorrin methyltransferase family.
 
 0.995
EKF04926.1
KEGG: npu:Npun_R1866 2.5e-219 uroporphyrin-III C-methyltransferase; K01719 uroporphyrinogen-III synthase K02303; Belongs to the precorrin methyltransferase family.
 
 
0.942
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.925
EKF04981.1
Porphobilinogen synthase; KEGG: ava:Ava_3297 5.4e-160 delta-aminolevulinic acid dehydratase K01698; Belongs to the ALAD family.
 
 
 0.894
EKF01035.1
Porphobilinogen synthase; KEGG: ana:all4725 3.7e-138 delta-aminolevulinic acid dehydratase K01698; Psort location: Cytoplasmic, score: 8.96; Belongs to the ALAD family.
 
 
 0.882
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.805
ccsA
Cytochrome c-type biogenesis protein CcsB; Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
 
    0.735
hemL
KEGG: ava:Ava_4920 3.9e-221 glutamate-1-semialdehyde aminotransferase K01845; Psort location: Cytoplasmic, score: 9.97.
 
  
 0.656
ligA
DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
      
 0.599
Your Current Organism:
Tolypothrix sp. PCC7601
NCBI taxonomy Id: 1188
Other names: Calothrix sp. PCC 7601, Fremyella diplosiphon ACMM 396, Fremyella diplosiphon IAM M-100, Fremyella diplosiphon UTEX B 481, Microchaete diplosiphon UTEX B 481, T. sp. PCC 7601, Tolypothrix (Calothrix) sp. PCC 7601, Tolypothrix sp. PCC 7601, Tolypothrix sp. PCC 7601 = UTEX B 481
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