Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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topA-2DNA topoisomerase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superc [...] (727 aa)    
Predicted Functional Partners:
EKF00393.1
KEGG: npu:Npun_R3585 0. ATP-dependent DNA helicase RecQ; K03654 ATP-dependent DNA helicase RecQ; Psort location: Cytoplasmic, score: 9.97.
   
 0.920
EKF01112.1
ATP-dependent helicase RecQ; KEGG: npu:Npun_F0932 4.3e-215 ATP-dependent DNA helicase RecQ; K03654 ATP-dependent DNA helicase RecQ; Psort location: CytoplasmicMembrane, score: 8.46.
   
 0.918
recA
Recombination protein A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 
 0.899
EKF02051.1
Tetratricopeptide repeat protein; KEGG: cbb:CLD_1251 6.1e-14 pcrA; ATP-dependent DNA helicase PcrA K03657; Psort location: Cytoplasmic, score: 9.97.
   
 0.881
EKF03031.1
Excision endonuclease subunit UvrD; KEGG: npu:Npun_R1007 0. ATP-dependent DNA helicase PcrA; K03657 DNA helicase II / ATP-dependent DNA helicase PcrA; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.863
EKF04457.1
ATP-dependent DNA helicase; KEGG: cgl:NCgl0704 9.8e-42 cgl0735; putative helicase K01529; Psort location: Cytoplasmic, score: 8.96.
   
 0.843
EKE97437.1
KEGG: ava:Ava_1425 0. UvrD/REP helicase; K03657 DNA helicase II / ATP-dependent DNA helicase PcrA; Psort location: Cytoplasmic, score: 8.96.
   
 0.843
EKF02439.1
Hypothetical protein; KEGG: sml:Smlt0109 0.27 gltB; glutamate synthase subunit alpha K00265.
   
 0.843
EKE98065.1
Hypothetical protein; KEGG: rha:RHA1_ro10332 0.46 long chain acy-CoA dehydrogenase K00257.
   
 0.834
polA
DNA-directed DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 
 0.816
Your Current Organism:
Tolypothrix sp. PCC7601
NCBI taxonomy Id: 1188
Other names: Calothrix sp. PCC 7601, Fremyella diplosiphon ACMM 396, Fremyella diplosiphon IAM M-100, Fremyella diplosiphon UTEX B 481, Microchaete diplosiphon UTEX B 481, T. sp. PCC 7601, Tolypothrix (Calothrix) sp. PCC 7601, Tolypothrix sp. PCC 7601, Tolypothrix sp. PCC 7601 = UTEX B 481
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