dnaK protein (Mycoplasma auris) - STRING interaction network

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dnaK

Chaperone protein DnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. (596 aa)

Predicted Functional Partners:

grpE

0.999

dnaJ

0.999

clpB

0.998

rplP

0.990

nifU

0.958

hrcA

0.928

rpsB

0.907

rplJ

0.907

eno

0.903

rpsC

0.902

Your Current Organism:

Mycoplasma auris

NCBI taxonomy Id: 1188233
Other names: M. auris 15026, Mycoplasma auris 15026

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
clpB	dnaJ	MAU_4230	MAU_4960	Chaperone ClpB; Belongs to the ClpA/ClpB family.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.940
clpB	dnaK	MAU_4230	MAU_0140	Chaperone ClpB; Belongs to the ClpA/ClpB family.	Chaperone protein DnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.998
clpB	grpE	MAU_4230	MAU_0690	Chaperone ClpB; Belongs to the ClpA/ClpB family.	Heat shock GrpE protein (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Seve [...]	0.890
clpB	hrcA	MAU_4230	MAU_0700	Chaperone ClpB; Belongs to the ClpA/ClpB family.	Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.718
dnaJ	clpB	MAU_4960	MAU_4230	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	Chaperone ClpB; Belongs to the ClpA/ClpB family.	0.940
dnaJ	dnaK	MAU_4960	MAU_0140	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	Chaperone protein DnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.999
dnaJ	grpE	MAU_4960	MAU_0690	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	Heat shock GrpE protein (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Seve [...]	0.977
dnaJ	hrcA	MAU_4960	MAU_0700	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.747
dnaJ	nifU	MAU_4960	MAU_0200	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	Aminotransferase protein U (nitrogen fixation protein NifU).	0.484
dnaJ	rplP	MAU_4960	MAU_3300	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family.	0.913
dnaJ	rpsB	MAU_4960	MAU_1590	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family.	0.905
dnaK	clpB	MAU_0140	MAU_4230	Chaperone protein DnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family.	Chaperone ClpB; Belongs to the ClpA/ClpB family.	0.998
dnaK	dnaJ	MAU_0140	MAU_4960	Chaperone protein DnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.999
dnaK	eno	MAU_0140	MAU_5390	Chaperone protein DnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family.	Enolase (2-phosphoglyceratedehydratase,2-phospho-D-glycerate hydro-lyase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.	0.903
dnaK	grpE	MAU_0140	MAU_0690	Chaperone protein DnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat shock GrpE protein (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Seve [...]	0.999
dnaK	hrcA	MAU_0140	MAU_0700	Chaperone protein DnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family.	Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.928
dnaK	nifU	MAU_0140	MAU_0200	Chaperone protein DnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family.	Aminotransferase protein U (nitrogen fixation protein NifU).	0.958
dnaK	rplJ	MAU_0140	MAU_3010	Chaperone protein DnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family.	50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.	0.907
dnaK	rplP	MAU_0140	MAU_3300	Chaperone protein DnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family.	50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family.	0.990
dnaK	rpsB	MAU_0140	MAU_1590	Chaperone protein DnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family.	30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family.	0.907