STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (281 aa)    
Predicted Functional Partners:
polA
DNA polymerase I, 5'-3' exonuclease.
  
 
 0.795
rpoD
RNA polymerase sigma-A factor rpoD.
  
    0.764
dnaG
DNA primase.
       0.751
glyS
Glycyl-tRNA synthetase.
       0.717
ung
Uracil-DNA glycosylase; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
   
 
 0.652
recA
Recombinase A.
   
 
 0.583
ffh
Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
  
    0.571
dinP
DNA polymerase IV (DinB).
  
 
 0.549
prkC
Serine/threonine protein kinase.
     
 0.511
topA
DNA topoisomerase I.
   
 
 0.504
Your Current Organism:
Mycoplasma alkalescens
NCBI taxonomy Id: 1188234
Other names: M. alkalescens 14918, Mycoplasma alkalescens 14918
Server load: low (12%) [HD]