oppF protein (Mycoplasma alkalescens) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

oppF

Oligopeptide transport ATP-binding protein; Overlaps another CDS with the same product name. (837 aa)

Predicted Functional Partners:

oppD

0.999

oppC-2

0.999

oppB-2

0.999

oppC-1

0.994

oppB-1

0.982

cbiQ

0.977

oppA

0.934

macB

0.883

phnC-1

0.816

cbiO1

0.803

Your Current Organism:

Mycoplasma alkalescens

NCBI taxonomy Id: 1188234
Other names: M. alkalescens 14918, Mycoplasma alkalescens 14918

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cbiO1	cbiQ	MALK_0380	MALK_0360	Cobalt import ATP-binding protein cbiO 1; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	Cobalt ABC transporter permease protein.	0.999
cbiO1	macB	MALK_0380	MALK_2840	Cobalt import ATP-binding protein cbiO 1; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	ABC transporter ATP-binding protein.	0.516
cbiO1	oppF	MALK_0380	MALK_1560	Cobalt import ATP-binding protein cbiO 1; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	Oligopeptide transport ATP-binding protein; Overlaps another CDS with the same product name.	0.803
cbiQ	cbiO1	MALK_0360	MALK_0380	Cobalt ABC transporter permease protein.	Cobalt import ATP-binding protein cbiO 1; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	0.999
cbiQ	oppF	MALK_0360	MALK_1560	Cobalt ABC transporter permease protein.	Oligopeptide transport ATP-binding protein; Overlaps another CDS with the same product name.	0.977
macB	cbiO1	MALK_2840	MALK_0380	ABC transporter ATP-binding protein.	Cobalt import ATP-binding protein cbiO 1; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	0.516
macB	oppF	MALK_2840	MALK_1560	ABC transporter ATP-binding protein.	Oligopeptide transport ATP-binding protein; Overlaps another CDS with the same product name.	0.883
oppA	oppB-2	MALK_1600	MALK_1590	Oligopeptide ABC transporter substrate-binding protein.	Oligopeptide transport system permease protein.	0.827
oppA	oppC-2	MALK_1600	MALK_1580	Oligopeptide ABC transporter substrate-binding protein.	Oligopeptide ABC transporter, permease protein.	0.827
oppA	oppD	MALK_1600	MALK_1570	Oligopeptide ABC transporter substrate-binding protein.	Oligopeptide transport ATP-binding protein; Overlaps another CDS with the same product name.	0.799
oppA	oppF	MALK_1600	MALK_1560	Oligopeptide ABC transporter substrate-binding protein.	Oligopeptide transport ATP-binding protein; Overlaps another CDS with the same product name.	0.934
oppB-1	oppB-2	MALK_0790	MALK_1590	Oligopeptide ABC transporter, permease protein.	Oligopeptide transport system permease protein.	0.969
oppB-1	oppC-1	MALK_0790	MALK_0800	Oligopeptide ABC transporter, permease protein.	Oligopeptide transport system permease protein.	0.996
oppB-1	oppC-2	MALK_0790	MALK_1580	Oligopeptide ABC transporter, permease protein.	Oligopeptide ABC transporter, permease protein.	0.983
oppB-1	oppD	MALK_0790	MALK_1570	Oligopeptide ABC transporter, permease protein.	Oligopeptide transport ATP-binding protein; Overlaps another CDS with the same product name.	0.990
oppB-1	oppF	MALK_0790	MALK_1560	Oligopeptide ABC transporter, permease protein.	Oligopeptide transport ATP-binding protein; Overlaps another CDS with the same product name.	0.982
oppB-2	oppA	MALK_1590	MALK_1600	Oligopeptide transport system permease protein.	Oligopeptide ABC transporter substrate-binding protein.	0.827
oppB-2	oppB-1	MALK_1590	MALK_0790	Oligopeptide transport system permease protein.	Oligopeptide ABC transporter, permease protein.	0.969
oppB-2	oppC-1	MALK_1590	MALK_0800	Oligopeptide transport system permease protein.	Oligopeptide transport system permease protein.	0.996
oppB-2	oppC-2	MALK_1590	MALK_1580	Oligopeptide transport system permease protein.	Oligopeptide ABC transporter, permease protein.	0.999

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034654

Nucleobase-containing compound biosynthetic process

10 of 150

1.39

2.51

4.19e-12

GO:0006796

Phosphate-containing compound metabolic process

10 of 293

1.1

1.48

1.77e-09

GO:0044237

Cellular metabolic process

11 of 1599

0.4

0.34

0.00091

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

9 of 10

2.52

8.24

4.91e-18

GO:0046961

Proton-transporting ATPase activity, rotational mechanism

2 of 3

2.39

1.33

0.0034

GO:0003824

Catalytic activity

11 of 2004

0.3

0.25

0.0178

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045259

Proton-transporting ATP synthase complex

9 of 9

2.56

8.79

4.58e-19

GO:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

5 of 5

2.56

4.87

3.47e-10

GO:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

4 of 4

2.56

3.87

3.98e-08

GO:0032991

Protein-containing complex

10 of 227

1.21

1.83

1.41e-10

GO:0005886

Plasma membrane

9 of 557

0.77

0.74

1.24e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:308

ATP synthesis

10 of 11

2.52

9.31

1.11e-20

CL:311

Proton-transporting ATP synthase complex, catalytic core F(1)

6 of 6

2.56

5.68

6.37e-12

CL:132

Ribosome, and ATP synthesis

11 of 99

1.61

3.76

1.67e-15

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lmd00190

Oxidative phosphorylation

10 of 48

1.88

5.23

2.10e-16

lmd01100

Metabolic pathways

9 of 810

0.61

0.49

0.0012

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045259

Proton-transporting ATP synthase complex

9 of 10

2.52

8.4

2.00e-18

GOCC:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

5 of 5

2.56

4.65

9.98e-10

GOCC:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

4 of 5

2.47

3.49

1.92e-07

GOCC:0032991

Protein-containing complex

10 of 545

0.83

0.86

8.33e-07

GOCC:0005622

Intracellular

11 of 1572

0.41

0.35

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0066

ATP synthesis

9 of 9

2.56

8.71

7.31e-19

KW-0375

Hydrogen ion transport

9 of 11

2.48

8.35

1.26e-18

KW-0139

CF(1)

5 of 5

2.56

4.72

6.94e-10

KW-0138

CF(0)

4 of 4

2.56

3.77

6.35e-08

KW-1003

Cell membrane

9 of 203

1.21

1.73

4.60e-09

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02874

ATP synthase alpha/beta family, beta-barrel domain

2 of 2

2.56

0.91

0.0224

PF00430

ATP synthase B/B CF(0)

2 of 2

2.56

0.91

0.0224

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