| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| glyA | hemK | MALK_4080 | MALK_0670 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Modification methylase HemK. | 0.569 |
| glyA | metK | MALK_4080 | MALK_6350 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | S-adenosylmethionine synthetase. | 0.606 |
| glyA | metS | MALK_4080 | MALK_2470 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Methionyl-tRNA synthetase (Methionine-tRNAligase, MetRS). | 0.754 |
| glyA | pdhD-2 | MALK_4080 | MALK_3490 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Dihydrolipoamide dehydrogenase. | 0.997 |
| glyA | pgk | MALK_4080 | MALK_6360 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoglycerate kinase. | 0.498 |
| glyA | pheT | MALK_4080 | MALK_4900 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phenylalanyl-tRNA synthetase beta chain (PheT). | 0.564 |
| glyA | polA | MALK_4080 | MALK_5390 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | DNA polymerase I, 5'-3' exonuclease. | 0.783 |
| hemK | glyA | MALK_0670 | MALK_4080 | Modification methylase HemK. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.569 |
| hemK | metK | MALK_0670 | MALK_6350 | Modification methylase HemK. | S-adenosylmethionine synthetase. | 0.700 |
| hemK | metS | MALK_0670 | MALK_2470 | Modification methylase HemK. | Methionyl-tRNA synthetase (Methionine-tRNAligase, MetRS). | 0.438 |
| marMP | metK | MALK_6570 | MALK_6350 | C-5 cytosine-specific DNA methyltransferase. | S-adenosylmethionine synthetase. | 0.617 |
| metK | glyA | MALK_6350 | MALK_4080 | S-adenosylmethionine synthetase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.606 |
| metK | hemK | MALK_6350 | MALK_0670 | S-adenosylmethionine synthetase. | Modification methylase HemK. | 0.700 |
| metK | marMP | MALK_6350 | MALK_6570 | S-adenosylmethionine synthetase. | C-5 cytosine-specific DNA methyltransferase. | 0.617 |
| metK | metS | MALK_6350 | MALK_2470 | S-adenosylmethionine synthetase. | Methionyl-tRNA synthetase (Methionine-tRNAligase, MetRS). | 0.728 |
| metK | pdhD-2 | MALK_6350 | MALK_3490 | S-adenosylmethionine synthetase. | Dihydrolipoamide dehydrogenase. | 0.604 |
| metK | pgk | MALK_6350 | MALK_6360 | S-adenosylmethionine synthetase. | Phosphoglycerate kinase. | 0.692 |
| metK | pheT | MALK_6350 | MALK_4900 | S-adenosylmethionine synthetase. | Phenylalanyl-tRNA synthetase beta chain (PheT). | 0.638 |
| metK | polA | MALK_6350 | MALK_5390 | S-adenosylmethionine synthetase. | DNA polymerase I, 5'-3' exonuclease. | 0.751 |
| metK | potB | MALK_6350 | MALK_4320 | S-adenosylmethionine synthetase. | Spermidine/putrescine ABC transporter permease protein potB. | 0.614 |