SJZ35127.1 protein (Anaerorhabdus furcosa) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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Score

SJZ35127.1

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (553 aa)

Predicted Functional Partners:

SJZ35096.1

0.980

SJZ35079.1

0.931

SJZ89507.1

0.906

SJZ36726.1

0.905

SJZ80902.1

0.905

SJZ40173.1

0.902

SKA04281.1

0.901

SJZ98873.1

0.876

SJZ64526.1

0.850

SJZ98027.1

0.846

Your Current Organism:

Anaerorhabdus furcosa

NCBI taxonomy Id: 118967
Other names: A. furcosa, ATCC 25662, Bacillus furcosus, Bacteroides furcosus, Fusiformis furcosus, Pseudobacterium furcosum, Ristella furcosa, VPI 3253

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SJZ35079.1	SJZ35096.1	SAMN02745191_0166	SAMN02745191_0167	iron(III) transport system substrate-binding protein.	Two-component system, response regulator YesN.	0.873
SJZ35079.1	SJZ35127.1	SAMN02745191_0166	SAMN02745191_0168	iron(III) transport system substrate-binding protein.	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	0.931
SJZ35096.1	SJZ35079.1	SAMN02745191_0167	SAMN02745191_0166	Two-component system, response regulator YesN.	iron(III) transport system substrate-binding protein.	0.873
SJZ35096.1	SJZ35127.1	SAMN02745191_0167	SAMN02745191_0168	Two-component system, response regulator YesN.	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	0.980
SJZ35096.1	SJZ36726.1	SAMN02745191_0167	SAMN02745191_0263	Two-component system, response regulator YesN.	Two component transcriptional regulator, LytTR family.	0.504
SJZ35096.1	SJZ40173.1	SAMN02745191_0167	SAMN02745191_0476	Two-component system, response regulator YesN.	Histidine kinase.	0.753
SJZ35096.1	SJZ64526.1	SAMN02745191_0167	SAMN02745191_1191	Two-component system, response regulator YesN.	Ribose transport system substrate-binding protein.	0.633
SJZ35096.1	SJZ80902.1	SAMN02745191_0167	SAMN02745191_1718	Two-component system, response regulator YesN.	Two component transcriptional regulator, LytTR family.	0.523
SJZ35096.1	SJZ89507.1	SAMN02745191_0167	SAMN02745191_1961	Two-component system, response regulator YesN.	Two component transcriptional regulator, LytTR family.	0.509
SJZ35096.1	SJZ98027.1	SAMN02745191_0167	SAMN02745191_2283	Two-component system, response regulator YesN.	Methyl-galactoside transport system substrate-binding protein.	0.640
SJZ35096.1	SJZ98873.1	SAMN02745191_0167	SAMN02745191_2322	Two-component system, response regulator YesN.	Two component transcriptional regulator, LytTR family.	0.437
SJZ35096.1	SKA04281.1	SAMN02745191_0167	SAMN02745191_0052	Two-component system, response regulator YesN.	Two component transcriptional regulator, LytTR family.	0.520
SJZ35127.1	SJZ35079.1	SAMN02745191_0168	SAMN02745191_0166	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	iron(III) transport system substrate-binding protein.	0.931
SJZ35127.1	SJZ35096.1	SAMN02745191_0168	SAMN02745191_0167	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	Two-component system, response regulator YesN.	0.980
SJZ35127.1	SJZ36726.1	SAMN02745191_0168	SAMN02745191_0263	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	Two component transcriptional regulator, LytTR family.	0.905
SJZ35127.1	SJZ40173.1	SAMN02745191_0168	SAMN02745191_0476	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	Histidine kinase.	0.902
SJZ35127.1	SJZ64526.1	SAMN02745191_0168	SAMN02745191_1191	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	Ribose transport system substrate-binding protein.	0.850
SJZ35127.1	SJZ80902.1	SAMN02745191_0168	SAMN02745191_1718	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	Two component transcriptional regulator, LytTR family.	0.905
SJZ35127.1	SJZ89507.1	SAMN02745191_0168	SAMN02745191_1961	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	Two component transcriptional regulator, LytTR family.	0.906
SJZ35127.1	SJZ98027.1	SAMN02745191_0168	SAMN02745191_2283	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.	Methyl-galactoside transport system substrate-binding protein.	0.846

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006261

DNA-templated DNA replication

11 of 92

2.37

9.31

1.49e-22

GO:0000727

Double-strand break repair via break-induced replication

7 of 13

3.02

8.39

1.68e-16

GO:0006268

DNA unwinding involved in DNA replication

7 of 18

2.88

7.91

7.80e-16

GO:0006270

DNA replication initiation

6 of 22

2.72

6.18

1.31e-12

GO:1902969

Mitotic DNA replication

4 of 12

2.81

4.11

2.29e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003697

Single-stranded DNA binding

6 of 81

2.16

3.91

4.50e-09

GO:0003678

DNA helicase activity

5 of 52

2.27

3.56

6.68e-08

GO:0140097

Catalytic activity, acting on DNA

6 of 208

1.75

2.61

3.60e-07

GO:0003688

DNA replication origin binding

3 of 12

2.69

2.58

1.71e-05

GO:0016887

ATP hydrolysis activity

4 of 302

1.41

1.07

0.0030

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071162

CMG complex

7 of 12

3.05

8.84

2.54e-17

GO:0000228

Nuclear chromosome

11 of 138

2.19

8.06

1.60e-21

GO:0042555

MCM complex

5 of 11

2.95

5.83

1.34e-11

GO:0043596

Nuclear replication fork

3 of 20

2.46

2.56

1.48e-05

GO:0031298

Replication fork protection complex

2 of 2

3.29

2.19

0.00011

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:32828016

(2020) Generation and characterization of keap1a- and keap1b-knockout zebrafish.

2 of 8

2.69

0.82

0.0328

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7155

DNA replication preinitiation complex, and CDC6 association with the ORC:origin complex

10 of 29

2.83

11.78

2.95e-24

CL:7153

Activation of the pre-replicative complex, and Regulation of DNA-directed DNA polymerase activity

11 of 49

2.64

11.68

1.49e-25

CL:7158

CMG complex

8 of 12

3.11

10.5

1.78e-20

CL:7161

MCM N-terminal domain

4 of 5

3.19

4.66

3.17e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tru03030

DNA replication

6 of 36

2.51

5.76

3.00e-12

tru04110

Cell cycle

6 of 126

1.97

3.72

1.84e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-68962

Activation of the pre-replicative complex

7 of 37

2.57

6.63

5.12e-14

MAP-176187

Activation of ATR in response to replication stress

6 of 39

2.48

5.39

1.55e-11

MAP-69206

G1/S Transition

7 of 139

1.99

4.21

7.97e-11

MAP-69306

DNA Replication

8 of 208

1.87

4.12

1.26e-11

MAP-69239

Synthesis of DNA

7 of 149

1.96

4.1

1.02e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042555

MCM complex

5 of 10

2.99

5.53

5.59e-11

GOCC:0031261

DNA replication preinitiation complex

2 of 6

2.81

1.26

0.0051

GOCC:0032991

Protein-containing complex

9 of 4666

0.57

0.38

0.0202

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0235

DNA replication

7 of 32

2.63

7.23

4.14e-15

KW-0347

Helicase

5 of 41

2.37

4.27

2.80e-09

KW-0539

Nucleus

8 of 1096

1.15

1.41

7.82e-07

KW-0131

Cell cycle

2 of 25

2.19

1.28

0.0039

KW-0238

DNA-binding

6 of 728

1.2

1.27

5.30e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF14551

MCM N-terminal domain

2 of 3

3.11

1.25

0.0055

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR027925

MCM N-terminal domain

5 of 6

3.21

5.72

3.47e-11

IPR018525

Mini-chromosome maintenance, conserved site

5 of 6

3.21

5.72

3.47e-11

IPR041562

MCM, AAA-lid domain

5 of 7

3.14

5.7

3.47e-11

IPR033762

MCM OB domain

5 of 7

3.14

5.7

3.47e-11

IPR001208

MCM domain

5 of 7

3.14

5.7

3.47e-11

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00350

Minichromosome maintenance proteins

2 of 2

3.29

1.64

0.0011

SM00382

ATPases associated with a variety of cellular activities

3 of 129

1.66

0.91

0.0142

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