node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHM53324.1 | SHM63411.1 | SAMN05216593_101394 | SAMN05216593_10241 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | 0.946 |
SHM53324.1 | SHM81209.1 | SAMN05216593_101394 | SAMN05216593_103294 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine dehydrogenase. | 0.951 |
SHM53324.1 | SHN09274.1 | SAMN05216593_101394 | SAMN05216593_107179 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoserine phosphatase. | 0.871 |
SHM53324.1 | SHN16287.1 | SAMN05216593_101394 | SAMN05216593_110184 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine biosynthesis protein MetW. | 0.615 |
SHM53324.1 | SHN17195.1 | SAMN05216593_101394 | SAMN05216593_11144 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoserine phosphatase. | 0.803 |
SHM53324.1 | SHN27264.1 | SAMN05216593_101394 | SAMN05216593_1213 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.487 |
SHM53324.1 | glyA | SAMN05216593_101394 | SAMN05216593_106148 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.856 |
SHM53324.1 | glyA-2 | SAMN05216593_101394 | SAMN05216593_109120 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.856 |
SHM53324.1 | metXS | SAMN05216593_101394 | SAMN05216593_110185 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | 0.946 |
SHM53324.1 | metZ | SAMN05216593_101394 | SAMN05216593_117114 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.966 |
SHM63411.1 | SHM53324.1 | SAMN05216593_10241 | SAMN05216593_101394 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.946 |
SHM63411.1 | SHM81209.1 | SAMN05216593_10241 | SAMN05216593_103294 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Homoserine dehydrogenase. | 0.888 |
SHM63411.1 | SHN09274.1 | SAMN05216593_10241 | SAMN05216593_107179 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Phosphoserine phosphatase. | 0.766 |
SHM63411.1 | SHN16287.1 | SAMN05216593_10241 | SAMN05216593_110184 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Methionine biosynthesis protein MetW. | 0.832 |
SHM63411.1 | SHN17195.1 | SAMN05216593_10241 | SAMN05216593_11144 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Phosphoserine phosphatase. | 0.720 |
SHM63411.1 | SHN27264.1 | SAMN05216593_10241 | SAMN05216593_1213 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.743 |
SHM63411.1 | glyA | SAMN05216593_10241 | SAMN05216593_106148 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.739 |
SHM63411.1 | glyA-2 | SAMN05216593_10241 | SAMN05216593_109120 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.739 |
SHM63411.1 | metXS | SAMN05216593_10241 | SAMN05216593_110185 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | 0.797 |
SHM63411.1 | metZ | SAMN05216593_10241 | SAMN05216593_117114 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.798 |