STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
panBKetopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (266 aa)    
Predicted Functional Partners:
panC
Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
 
 0.999
panD
L-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
 
  
 0.995
SHN11326.1
2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
 
  
 0.901
SHN17222.1
2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
    
 0.881
SHN27383.1
2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase.
 
 
 0.793
SHN12196.1
Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Belongs to the NadC/ModD family.
     0.789
SHM78593.1
Branched chain amino acid aminotransferase apoenzyme.
    
 0.783
SHN25018.1
4-amino-4-deoxychorismate lyase.
    
 0.777
ilvD
Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family.
     
 0.755
birA
Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
  
  
 0.738
Your Current Organism:
Pseudomonas asturiensis
NCBI taxonomy Id: 1190415
Other names: CECT 8095, LMG 26898, LMG:26898, LPPA 221, P. asturiensis, Pseudomonas asturiensis Gonzalez et al. 2013, Pseudomonas sp. LPPA 221, Pseudomonas sp. LPPA 816
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