STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MROS_01662-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (386 aa)    
Predicted Functional Partners:
MROS_0233
3-isopropylmalate dehydratase, small subunit, putative; Belongs to the LeuD family.
 
 
 0.971
MROS_0234
3-isopropylmalate dehydratase large subunit; Belongs to the aconitase/IPM isomerase family.
 
 0.956
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.931
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
  
 0.899
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.857
MROS_2223
3-isopropylmalate dehydrogenase.
 
 0.832
MROS_0167
Lysine biosynthesis protein LysW.
       0.781
MROS_0239
Acetolactate synthase, large subunit, biosynthetic type.
 
 
 0.781
MROS_1181
Para-aminobenzoate synthase component I.
  
 
 0.738
MROS_2020
Branched-chain amino acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.738
Your Current Organism:
Melioribacter roseus
NCBI taxonomy Id: 1191523
Other names: M. roseus P3M-2, Melioribacter roseus P3M-2, Melioribacter roseus str. P3M-2, Melioribacter roseus strain P3M-2
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