STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (311 aa)    
Predicted Functional Partners:
MROS_0610
Uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 0.999
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.999
MROS_0604
Porphobilinogen synthase; Belongs to the ALAD family.
 
 0.998
MROS_0865
uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
  
 0.995
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.988
hemL
Glutamate-1-semialdehyde 2,1-aminomutase.
  
 0.971
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.841
MROS_0608
Oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family.
  
  
 0.831
MROS_0613
Cytochrome c assembly protein.
       0.772
MROS_1486
Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.762
Your Current Organism:
Melioribacter roseus
NCBI taxonomy Id: 1191523
Other names: M. roseus P3M-2, Melioribacter roseus P3M-2, Melioribacter roseus str. P3M-2, Melioribacter roseus strain P3M-2
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