MROS_1373 protein (Melioribacter roseus) - STRING interaction network

Nodes:

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

MROS_1373

Aspartate transaminase. (405 aa)

Predicted Functional Partners:

pckA

0.960

MROS_1573

0.958

MROS_0712

0.946

hisC

0.926

mdh

0.924

argG

0.923

MROS_1935

0.921

MROS_1206

0.919

MROS_2027

0.916

MROS_1175

0.915

Your Current Organism:

Melioribacter roseus

NCBI taxonomy Id: 1191523
Other names: M. roseus P3M-2, Melioribacter roseus P3M-2, Melioribacter roseus str. P3M-2, Melioribacter roseus strain P3M-2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MROS_0712	MROS_1175	MROS_0712	MROS_1175	Glutamate synthase (ferredoxin).	Aromatic amino acid decarboxylase.	0.433
MROS_0712	MROS_1206	MROS_0712	MROS_1206	Glutamate synthase (ferredoxin).	1-pyrroline-5-carboxylate dehydrogenase.	0.948
MROS_0712	MROS_1373	MROS_0712	MROS_1373	Glutamate synthase (ferredoxin).	Aspartate transaminase.	0.946
MROS_0712	MROS_1573	MROS_0712	MROS_1573	Glutamate synthase (ferredoxin).	Phospho-2-dehydro-3-deoxyheptonate aldolase.	0.512
MROS_0712	MROS_2027	MROS_0712	MROS_2027	Glutamate synthase (ferredoxin).	Aminotransferase.	0.490
MROS_0712	argG	MROS_0712	MROS_0917	Glutamate synthase (ferredoxin).	Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily.	0.565
MROS_0712	mdh	MROS_0712	MROS_2852	Glutamate synthase (ferredoxin).	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.	0.890
MROS_0712	pckA	MROS_0712	MROS_1372	Glutamate synthase (ferredoxin).	Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.	0.868
MROS_1175	MROS_0712	MROS_1175	MROS_0712	Aromatic amino acid decarboxylase.	Glutamate synthase (ferredoxin).	0.433
MROS_1175	MROS_1373	MROS_1175	MROS_1373	Aromatic amino acid decarboxylase.	Aspartate transaminase.	0.915
MROS_1175	MROS_1573	MROS_1175	MROS_1573	Aromatic amino acid decarboxylase.	Phospho-2-dehydro-3-deoxyheptonate aldolase.	0.876
MROS_1175	hisC	MROS_1175	MROS_2793	Aromatic amino acid decarboxylase.	Histidinol phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.907
MROS_1206	MROS_0712	MROS_1206	MROS_0712	1-pyrroline-5-carboxylate dehydrogenase.	Glutamate synthase (ferredoxin).	0.948
MROS_1206	MROS_1373	MROS_1206	MROS_1373	1-pyrroline-5-carboxylate dehydrogenase.	Aspartate transaminase.	0.919
MROS_1206	pckA	MROS_1206	MROS_1372	1-pyrroline-5-carboxylate dehydrogenase.	Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.	0.410
MROS_1373	MROS_0712	MROS_1373	MROS_0712	Aspartate transaminase.	Glutamate synthase (ferredoxin).	0.946
MROS_1373	MROS_1175	MROS_1373	MROS_1175	Aspartate transaminase.	Aromatic amino acid decarboxylase.	0.915
MROS_1373	MROS_1206	MROS_1373	MROS_1206	Aspartate transaminase.	1-pyrroline-5-carboxylate dehydrogenase.	0.919
MROS_1373	MROS_1573	MROS_1373	MROS_1573	Aspartate transaminase.	Phospho-2-dehydro-3-deoxyheptonate aldolase.	0.958
MROS_1373	MROS_1935	MROS_1373	MROS_1935	Aspartate transaminase.	Prephenate dehydrogenase.	0.921

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034654

Nucleobase-containing compound biosynthetic process

10 of 150

1.39

2.51

4.19e-12

GO:0006796

Phosphate-containing compound metabolic process

10 of 293

1.1

1.48

1.77e-09

GO:0044237

Cellular metabolic process

11 of 1599

0.4

0.34

0.00091

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

9 of 10

2.52

8.24

4.91e-18

GO:0046961

Proton-transporting ATPase activity, rotational mechanism

2 of 3

2.39

1.33

0.0034

GO:0003824

Catalytic activity

11 of 2004

0.3

0.25

0.0178

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045259

Proton-transporting ATP synthase complex

9 of 9

2.56

8.79

4.58e-19

GO:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

5 of 5

2.56

4.87

3.47e-10

GO:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

4 of 4

2.56

3.87

3.98e-08

GO:0032991

Protein-containing complex

10 of 227

1.21

1.83

1.41e-10

GO:0005886

Plasma membrane

9 of 557

0.77

0.74

1.24e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:308

ATP synthesis

10 of 11

2.52

9.31

1.11e-20

CL:311

Proton-transporting ATP synthase complex, catalytic core F(1)

6 of 6

2.56

5.68

6.37e-12

CL:132

Ribosome, and ATP synthesis

11 of 99

1.61

3.76

1.67e-15

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lmd00190

Oxidative phosphorylation

10 of 48

1.88

5.23

2.10e-16

lmd01100

Metabolic pathways

9 of 810

0.61

0.49

0.0012

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045259

Proton-transporting ATP synthase complex

9 of 10

2.52

8.4

2.00e-18

GOCC:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

5 of 5

2.56

4.65

9.98e-10

GOCC:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

4 of 5

2.47

3.49

1.92e-07

GOCC:0032991

Protein-containing complex

10 of 545

0.83

0.86

8.33e-07

GOCC:0005622

Intracellular

11 of 1572

0.41

0.35

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0066

ATP synthesis

9 of 9

2.56

8.71

7.31e-19

KW-0375

Hydrogen ion transport

9 of 11

2.48

8.35

1.26e-18

KW-0139

CF(1)

5 of 5

2.56

4.72

6.94e-10

KW-0138

CF(0)

4 of 4

2.56

3.77

6.35e-08

KW-1003

Cell membrane

9 of 203

1.21

1.73

4.60e-09

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02874

ATP synthase alpha/beta family, beta-barrel domain

2 of 2

2.56

0.91

0.0224

PF00430

ATP synthase B/B CF(0)

2 of 2

2.56

0.91

0.0224

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