MROS_2255 protein (Melioribacter roseus) - STRING interaction network

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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[Homology]

Score

MROS_2255

Response regulator receiver sensor signal transduction histidine kinase. (533 aa)

Predicted Functional Partners:

MROS_2272

0.983

MROS_0589

0.963

MROS_2250

0.956

MROS_2190

0.949

MROS_0591

0.948

MROS_2015

0.947

MROS_0590

0.942

MROS_1661

0.937

MROS_2019

0.937

MROS_0118

0.930

Your Current Organism:

Melioribacter roseus

NCBI taxonomy Id: 1191523
Other names: M. roseus P3M-2, Melioribacter roseus P3M-2, Melioribacter roseus str. P3M-2, Melioribacter roseus strain P3M-2

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
MROS_0118	MROS_0589	Histidine kinase-like ATPase.	PAS/PAC sensor hybrid histidine kinase.	0.926
MROS_0118	MROS_0591	Histidine kinase-like ATPase.	GAF sensor hybrid histidine kinase.	0.960
MROS_0118	MROS_1661	Histidine kinase-like ATPase.	Multi-sensor hybrid histidine kinase.	0.950
MROS_0118	MROS_2015	Histidine kinase-like ATPase.	Response regulator receiver sensor signal transduction histidine kinase.	0.949
MROS_0118	MROS_2019	Histidine kinase-like ATPase.	PAS:Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase A-like protein.	0.949
MROS_0118	MROS_2190	Histidine kinase-like ATPase.	PAS/PAC sensor hybrid histidine kinase.	0.946
MROS_0118	MROS_2250	Histidine kinase-like ATPase.	PAS:Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase A-like protein.	0.955
MROS_0118	MROS_2255	Histidine kinase-like ATPase.	Response regulator receiver sensor signal transduction histidine kinase.	0.930
MROS_0118	MROS_2272	Histidine kinase-like ATPase.	Multi-sensor hybrid histidine kinase.	0.978
MROS_0589	MROS_0118	PAS/PAC sensor hybrid histidine kinase.	Histidine kinase-like ATPase.	0.926
MROS_0589	MROS_0590	PAS/PAC sensor hybrid histidine kinase.	Response regulator receiver protein.	0.891
MROS_0589	MROS_0591	PAS/PAC sensor hybrid histidine kinase.	GAF sensor hybrid histidine kinase.	0.931
MROS_0589	MROS_1661	PAS/PAC sensor hybrid histidine kinase.	Multi-sensor hybrid histidine kinase.	0.955
MROS_0589	MROS_2015	PAS/PAC sensor hybrid histidine kinase.	Response regulator receiver sensor signal transduction histidine kinase.	0.956
MROS_0589	MROS_2019	PAS/PAC sensor hybrid histidine kinase.	PAS:Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase A-like protein.	0.948
MROS_0589	MROS_2190	PAS/PAC sensor hybrid histidine kinase.	PAS/PAC sensor hybrid histidine kinase.	0.951
MROS_0589	MROS_2250	PAS/PAC sensor hybrid histidine kinase.	PAS:Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase A-like protein.	0.961
MROS_0589	MROS_2255	PAS/PAC sensor hybrid histidine kinase.	Response regulator receiver sensor signal transduction histidine kinase.	0.963
MROS_0589	MROS_2272	PAS/PAC sensor hybrid histidine kinase.	Multi-sensor hybrid histidine kinase.	0.990
MROS_0590	MROS_0589	Response regulator receiver protein.	PAS/PAC sensor hybrid histidine kinase.	0.891

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.812

expected number of edges:

22

PPI enrichment p-value:

0.000281

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009084

Glutamine family amino acid biosynthetic process

6 of 14

2.03

3.56

1.15e-08

GO:0009064

Glutamine family amino acid metabolic process

7 of 26

1.83

3.28

5.73e-09

GO:1901605

Alpha-amino acid metabolic process

8 of 68

1.47

2.35

1.15e-08

GO:1901607

Alpha-amino acid biosynthetic process

7 of 52

1.53

2.33

8.86e-08

GO:0006541

Glutamine metabolic process

4 of 14

1.85

2.07

3.42e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016639

Oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

3 of 3

2.4

1.75

0.00053

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

4 of 40

1.4

1.05

0.0032

GO:0004356

Glutamate-ammonia ligase activity

2 of 2

2.4

1.04

0.0123

GO:0004355

Glutamate synthase (NADPH) activity

2 of 2

2.4

1.04

0.0123

GO:0005488

Binding

10 of 1114

0.35

0.26

0.0403

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005622

Intracellular anatomical structure

10 of 1013

0.39

0.27

0.0397

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1753

Glutamine family amino acid biosynthetic process, and Alanine, aspartate and glutamate metabolism

5 of 19

1.82

2.26

8.69e-06

CL:1754

Mixed, incl. Nitrogen metabolism, and Carbapenem biosynthesis

4 of 12

1.92

2.11

3.70e-05

CL:1757

Oxidoreductase activity, acting on the CH-NH2 group of donors, and Aminotransferase class I and II

3 of 5

2.18

1.85

0.00027

CL:1691

Alpha-amino acid biosynthetic process, and Cysteine and methionine metabolism

6 of 50

1.48

1.82

8.69e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00250

Alanine, aspartate and glutamate metabolism

8 of 26

1.89

4.28

3.92e-12

map00910

Nitrogen metabolism

5 of 7

2.25

3.82

1.51e-08

map00220

Arginine biosynthesis

4 of 11

1.96

2.43

6.76e-06

map01230

Biosynthesis of amino acids

6 of 149

1.0

0.92

0.00029

map00630

Glyoxylate and dicarboxylate metabolism

2 of 17

1.47

0.69

0.0377

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01230

Glutamine synthetase, catalytic domain

2 of 2

2.4

1.13

0.0085

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