node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EPG75885.1 | guaA | LEP1GSC058_0623 | LEP1GSC058_2205 | Class I glutamine amidotransferase. | GMP synthase (glutamine-hydrolyzing). | 0.626 |
EPG75885.1 | guaB | LEP1GSC058_0623 | LEP1GSC058_0596 | Class I glutamine amidotransferase. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.968 |
EPG75885.1 | purA | LEP1GSC058_0623 | LEP1GSC058_2619 | Class I glutamine amidotransferase. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.547 |
EPG75885.1 | purH | LEP1GSC058_0623 | LEP1GSC058_0510 | Class I glutamine amidotransferase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.518 |
EPG75885.1 | surE | LEP1GSC058_0623 | LEP1GSC058_3842 | Class I glutamine amidotransferase. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.434 |
guaA | EPG75885.1 | LEP1GSC058_2205 | LEP1GSC058_0623 | GMP synthase (glutamine-hydrolyzing). | Class I glutamine amidotransferase. | 0.626 |
guaA | guaB | LEP1GSC058_2205 | LEP1GSC058_0596 | GMP synthase (glutamine-hydrolyzing). | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | hisB | LEP1GSC058_2205 | LEP1GSC058_3440 | GMP synthase (glutamine-hydrolyzing). | Imidazoleglycerol-phosphate dehydratase. | 0.475 |
guaA | purA | LEP1GSC058_2205 | LEP1GSC058_2619 | GMP synthase (glutamine-hydrolyzing). | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.942 |
guaA | purH | LEP1GSC058_2205 | LEP1GSC058_0510 | GMP synthase (glutamine-hydrolyzing). | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.894 |
guaA | rdgB | LEP1GSC058_2205 | LEP1GSC058_3790 | GMP synthase (glutamine-hydrolyzing). | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.969 |
guaA | surE | LEP1GSC058_2205 | LEP1GSC058_3842 | GMP synthase (glutamine-hydrolyzing). | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.943 |
guaB | EPG75885.1 | LEP1GSC058_0596 | LEP1GSC058_0623 | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Class I glutamine amidotransferase. | 0.968 |
guaB | guaA | LEP1GSC058_0596 | LEP1GSC058_2205 | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase (glutamine-hydrolyzing). | 0.999 |
guaB | hisB | LEP1GSC058_0596 | LEP1GSC058_3440 | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Imidazoleglycerol-phosphate dehydratase. | 0.925 |
guaB | hisE | LEP1GSC058_0596 | LEP1GSC058_1483 | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | phosphoribosyl-ATP diphosphatase. | 0.999 |
guaB | hisG | LEP1GSC058_0596 | LEP1GSC058_1269 | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.931 |
guaB | hisI | LEP1GSC058_0596 | LEP1GSC058_3806 | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | 0.999 |
guaB | purA | LEP1GSC058_0596 | LEP1GSC058_2619 | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.988 |
guaB | purH | LEP1GSC058_0596 | LEP1GSC058_0510 | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.984 |