node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCH69882.1 | fhs | BN10_430008 | BN10_680050 | Bifunctional purine biosynthesis protein purH (Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase) (fragment). | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.983 |
CCH69882.1 | fmt | BN10_430008 | BN10_550004 | Bifunctional purine biosynthesis protein purH (Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase) (fragment). | 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.868 |
CCH69882.1 | folD | BN10_430008 | BN10_1290001 | Bifunctional purine biosynthesis protein purH (Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase) (fragment). | Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.974 |
CCH69882.1 | gcvT | BN10_430008 | BN10_290005 | Bifunctional purine biosynthesis protein purH (Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase) (fragment). | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.930 |
CCH69882.1 | glyA | BN10_430008 | BN10_1140014 | Bifunctional purine biosynthesis protein purH (Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase) (fragment). | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.991 |
CCH69882.1 | metF | BN10_430008 | BN10_360044 | Bifunctional purine biosynthesis protein purH (Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase) (fragment). | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.617 |
CCH69882.1 | purD | BN10_430008 | BN10_650039 | Bifunctional purine biosynthesis protein purH (Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase) (fragment). | Phosphoribosylglycinamide synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the GARS family. | 0.992 |
CCH69882.1 | purL | BN10_430008 | BN10_650035 | Bifunctional purine biosynthesis protein purH (Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase) (fragment). | Phosphoribosylformyl-glycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.996 |
CCH69882.1 | purN | BN10_430008 | BN10_1120005 | Bifunctional purine biosynthesis protein purH (Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase) (fragment). | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
CCH69882.1 | purU | BN10_430008 | BN10_540066 | Bifunctional purine biosynthesis protein purH (Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase) (fragment). | Formyltetrahydrofolate hydrolase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.503 |
fhs | CCH69882.1 | BN10_680050 | BN10_430008 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional purine biosynthesis protein purH (Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase) (fragment). | 0.983 |
fhs | fmt | BN10_680050 | BN10_550004 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.600 |
fhs | folD | BN10_680050 | BN10_1290001 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.996 |
fhs | gcvT | BN10_680050 | BN10_290005 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.897 |
fhs | glyA | BN10_680050 | BN10_1140014 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.963 |
fhs | metF | BN10_680050 | BN10_360044 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.600 |
fhs | purD | BN10_680050 | BN10_650039 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the GARS family. | 0.777 |
fhs | purL | BN10_680050 | BN10_650035 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylformyl-glycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.957 |
fhs | purN | BN10_680050 | BN10_1120005 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.946 |
fhs | purU | BN10_680050 | BN10_540066 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Formyltetrahydrofolate hydrolase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.503 |