STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
glnEGlutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] (1004 aa)    
Predicted Functional Partners:
glnA-2
Putative glutamine synthetase 2; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the glutamine synthetase family.
  
  
 0.943
glnA
Glutamine synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.902
glnD
(Protein-PII) uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
 
   
 0.778
glnK
Nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB; Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the P(II) protein family.
 
 
 
 0.729
CCH71134.1
Putative ribonuclease D; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
  
     0.689
gltA-2
Glutamate synthase (large subunit); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
     
 0.655
CCH71551.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
  
     0.652
crgA
Conserved hypothetical protein; Involved in cell division; Belongs to the CrgA family.
  
   
 0.651
rbpA-2
Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
  
     0.620
CCH70486.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
  
     0.607
Your Current Organism:
Tetrasphaera elongata
NCBI taxonomy Id: 1193181
Other names: T. elongata Lp2, Tetrasphaera elongata DSM 14184, Tetrasphaera elongata Lp2, Tetrasphaera elongata str. Lp2, Tetrasphaera elongata strain Lp2, actinomycete Lp2
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