AHN25138.1 protein (Gilliamella apicola) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AHN25138.1

Putative Fe-S oxidoreductase. (308 aa)

Predicted Functional Partners:

AHN26002.1

0.630

AHN25880.1

0.570

AHN24690.1

0.442

AHN24691.1

0.418

Your Current Organism:

Gilliamella apicola

NCBI taxonomy Id: 1196095
Other names: ATCC BAA-2448, Candidatus Gilliamella apicola, G. apicola, Gilliamella apicola Kwong and Moran 2013, NCIMB 14804, strain wkB1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHN24690.1	AHN24691.1	GAPWK_0111	GAPWK_0112	Putative protease.	Putative protease.	0.990
AHN24690.1	AHN25138.1	GAPWK_0111	GAPWK_0561	Putative protease.	Putative Fe-S oxidoreductase.	0.442
AHN24690.1	AHN26002.1	GAPWK_0111	GAPWK_1427	Putative protease.	Putative lipid carrier protein.	0.937
AHN24691.1	AHN24690.1	GAPWK_0112	GAPWK_0111	Putative protease.	Putative protease.	0.990
AHN24691.1	AHN25138.1	GAPWK_0112	GAPWK_0561	Putative protease.	Putative Fe-S oxidoreductase.	0.418
AHN24691.1	AHN26002.1	GAPWK_0112	GAPWK_1427	Putative protease.	Putative lipid carrier protein.	0.838
AHN25138.1	AHN24690.1	GAPWK_0561	GAPWK_0111	Putative Fe-S oxidoreductase.	Putative protease.	0.442
AHN25138.1	AHN24691.1	GAPWK_0561	GAPWK_0112	Putative Fe-S oxidoreductase.	Putative protease.	0.418
AHN25138.1	AHN25880.1	GAPWK_0561	GAPWK_1303	Putative Fe-S oxidoreductase.	Sialic acid utilization regulator, RpiR family.	0.570
AHN25138.1	AHN26002.1	GAPWK_0561	GAPWK_1427	Putative Fe-S oxidoreductase.	Putative lipid carrier protein.	0.630
AHN25880.1	AHN25138.1	GAPWK_1303	GAPWK_0561	Sialic acid utilization regulator, RpiR family.	Putative Fe-S oxidoreductase.	0.570
AHN26002.1	AHN24690.1	GAPWK_1427	GAPWK_0111	Putative lipid carrier protein.	Putative protease.	0.937
AHN26002.1	AHN24691.1	GAPWK_1427	GAPWK_0112	Putative lipid carrier protein.	Putative protease.	0.838
AHN26002.1	AHN25138.1	GAPWK_1427	GAPWK_0561	Putative lipid carrier protein.	Putative Fe-S oxidoreductase.	0.630

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.841

expected number of edges:

16

PPI enrichment p-value:

7.42e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006783

Heme biosynthetic process

3 of 13

1.97

1.51

0.0010

GO:0045333

Cellular respiration

3 of 47

1.41

0.82

0.0155

GO:0006119

Oxidative phosphorylation

2 of 11

1.86

0.8

0.0292

GO:0022904

Respiratory electron transport chain

2 of 15

1.73

0.68

0.0473

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

5 of 19

2.02

2.81

1.06e-06

GO:0015078

Proton transmembrane transporter activity

5 of 19

2.02

2.81

1.06e-06

GO:0022853

Active ion transmembrane transporter activity

5 of 37

1.73

2.2

6.94e-06

GO:0004129

Cytochrome-c oxidase activity

3 of 5

2.38

2.19

7.10e-05

GO:0009055

Electron transfer activity

5 of 41

1.69

2.12

8.35e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070469

Respirasome

3 of 9

2.13

1.78

0.00034

GO:0016021

Integral component of membrane

8 of 885

0.56

0.38

0.0166

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3096

Mixed, incl. Cytochrome-c oxidase activity, and RDD family

7 of 11

2.41

5.72

1.63e-12

CL:3098

Cytochrome-c oxidase activity, and Rieske iron-sulphur protein

4 of 6

2.43

3.22

6.34e-07

CL:2786

Mixed, incl. Tetrapyrrole biosynthetic process, and Oxidative phosphorylation

9 of 198

1.26

1.83

1.17e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

7 of 58

1.69

2.98

4.33e-09

map00860

Porphyrin and chlorophyll metabolism

4 of 61

1.42

1.24

0.00084

map01100

Metabolic pathways

10 of 1709

0.37

0.28

0.0236

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

3 of 14

1.94

1.33

0.0024

GOCC:0005739

Mitochondrion

3 of 50

1.38

0.66

0.0392

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0249

Electron transport

4 of 7

2.36

3.0

1.51e-06

KW-0679

Respiratory chain

3 of 3

2.6

2.47

2.55e-05

KW-0408

Iron

5 of 68

1.47

1.67

3.38e-05

KW-0350

Heme biosynthesis

2 of 2

2.6

1.54

0.0015

KW-0186

Copper

2 of 3

2.43

1.45

0.0021

(more ...)

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