AHN26139.1 protein (Gilliamella apicola) - STRING interaction network

Nodes:

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

AHN26139.1

Long-chain-fatty-acid--CoA ligase. (259 aa)

Predicted Functional Partners:

AHN26138.1

0.990

AHN26886.1

0.670

AHN25984.1

0.655

AHN26541.1

0.654

AHN26113.1

0.585

AHN26810.1

0.583

AHN25982.1

0.567

AHN26264.1

0.544

AHN25983.1

0.513

AHN26175.1

0.490

Your Current Organism:

Gilliamella apicola

NCBI taxonomy Id: 1196095
Other names: ATCC BAA-2448, Candidatus Gilliamella apicola, G. apicola, Gilliamella apicola Kwong and Moran 2013, NCIMB 14804, strain wkB1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHN25982.1	AHN25983.1	GAPWK_1405	GAPWK_1406	YbtP.	YbtQ.	0.822
AHN25982.1	AHN25984.1	GAPWK_1405	GAPWK_1407	YbtP.	Transcriptional regulator, TetR family.	0.584
AHN25982.1	AHN26113.1	GAPWK_1405	GAPWK_1538	YbtP.	Hypothetical protein.	0.709
AHN25982.1	AHN26138.1	GAPWK_1405	GAPWK_1563	YbtP.	Long-chain-fatty-acid--CoA ligase.	0.563
AHN25982.1	AHN26139.1	GAPWK_1405	GAPWK_1564	YbtP.	Long-chain-fatty-acid--CoA ligase.	0.567
AHN25982.1	AHN26175.1	GAPWK_1405	GAPWK_1602	YbtP.	Nonribosomal peptide synthetase.	0.608
AHN25982.1	AHN26264.1	GAPWK_1405	GAPWK_1691	YbtP.	Hypothetical protein.	0.703
AHN25982.1	AHN26541.1	GAPWK_1405	GAPWK_1968	YbtP.	Hypothetical protein.	0.678
AHN25983.1	AHN25982.1	GAPWK_1406	GAPWK_1405	YbtQ.	YbtP.	0.822
AHN25983.1	AHN25984.1	GAPWK_1406	GAPWK_1407	YbtQ.	Transcriptional regulator, TetR family.	0.568
AHN25983.1	AHN26113.1	GAPWK_1406	GAPWK_1538	YbtQ.	Hypothetical protein.	0.675
AHN25983.1	AHN26138.1	GAPWK_1406	GAPWK_1563	YbtQ.	Long-chain-fatty-acid--CoA ligase.	0.554
AHN25983.1	AHN26139.1	GAPWK_1406	GAPWK_1564	YbtQ.	Long-chain-fatty-acid--CoA ligase.	0.513
AHN25983.1	AHN26175.1	GAPWK_1406	GAPWK_1602	YbtQ.	Nonribosomal peptide synthetase.	0.608
AHN25983.1	AHN26264.1	GAPWK_1406	GAPWK_1691	YbtQ.	Hypothetical protein.	0.692
AHN25983.1	AHN26541.1	GAPWK_1406	GAPWK_1968	YbtQ.	Hypothetical protein.	0.662
AHN25984.1	AHN25982.1	GAPWK_1407	GAPWK_1405	Transcriptional regulator, TetR family.	YbtP.	0.584
AHN25984.1	AHN25983.1	GAPWK_1407	GAPWK_1406	Transcriptional regulator, TetR family.	YbtQ.	0.568
AHN25984.1	AHN26113.1	GAPWK_1407	GAPWK_1538	Transcriptional regulator, TetR family.	Hypothetical protein.	0.687
AHN25984.1	AHN26138.1	GAPWK_1407	GAPWK_1563	Transcriptional regulator, TetR family.	Long-chain-fatty-acid--CoA ligase.	0.600

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.876

expected number of edges:

11

PPI enrichment p-value:

2.4e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045454

Cell redox homeostasis

3 of 20

2.33

1.29

0.0041

GO:0016259

Selenocysteine metabolic process

2 of 2

3.15

1.07

0.0121

GO:0006777

Mo-molybdopterin cofactor biosynthetic process

2 of 8

2.55

0.8

0.0347

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004791

Thioredoxin-disulfide reductase activity

3 of 9

2.68

2.33

5.04e-05

GO:0016783

Sulfurtransferase activity

3 of 10

2.63

2.32

5.04e-05

GO:0015035

Protein-disulfide reductase activity

4 of 37

2.19

2.27

3.53e-05

GO:0070279

Vitamin B6 binding

3 of 53

1.9

1.33

0.0023

GO:0050660

Flavin adenine dinucleotide binding

3 of 82

1.72

1.09

0.0060

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17367

Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor, and Redox-active center

4 of 13

2.64

3.19

1.05e-06

CL:17369

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain, and Glutathione oxidoreductase activity

2 of 5

2.75

1.21

0.0063

CL:19473

Mitochondrial iron-sulfur cluster biogenesis, and Selenocysteine metabolic process

2 of 8

2.55

1.07

0.0112

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00450

Selenocompound metabolism

6 of 17

2.7

6.38

4.48e-13

map04122

Sulfur relay system

2 of 10

2.45

1.38

0.0029

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2408522

Selenoamino acid metabolism

5 of 22

2.51

4.18

7.96e-09

MAP-3299685

Detoxification of Reactive Oxygen Species

4 of 35

2.21

2.63

6.11e-06

MAP-71291

Metabolism of amino acids and derivatives

6 of 247

1.54

1.95

6.11e-06

MAP-5263617

Metabolism of ingested MeSeO2H into MeSeH

2 of 2

3.15

1.69

0.00090

MAP-499943

Interconversion of nucleotide di- and triphosphates

3 of 40

2.03

1.55

0.00090

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0676

Redox-active center

4 of 15

2.58

3.56

1.77e-07

KW-0663

Pyridoxal phosphate

3 of 38

2.05

1.69

0.00047

KW-0520

NAD

3 of 60

1.85

1.44

0.0012

KW-0274

FAD

3 of 63

1.83

1.43

0.0012

KW-0560

Oxidoreductase

3 of 245

1.24

0.64

0.0342

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

3 of 5

2.93

2.49

2.86e-05

PF00890

FAD binding domain

3 of 11

2.59

2.18

9.28e-05

PF00070

Pyridine nucleotide-disulphide oxidoreductase

2 of 4

2.85

1.3

0.0044

PF01212

Beta-eliminating lyase

2 of 7

2.61

1.15

0.0080

PF00266

Aminotransferase class-V

2 of 8

2.55

1.15

0.0080

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