AHN26509.1 protein (Gilliamella apicola) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

AHN26509.1

tssJ. (171 aa)

Predicted Functional Partners:

AHN26508.1

0.987

AHN26510.1

0.984

AHN26511.1

0.972

AHN26519.1

0.939

AHN26512.1

0.938

AHN26522.1

0.938

AHN26513.1

0.937

AHN26521.1

0.913

AHN26520.1

0.901

AHN26515.1

0.891

Your Current Organism:

Gilliamella apicola

NCBI taxonomy Id: 1196095
Other names: ATCC BAA-2448, Candidatus Gilliamella apicola, G. apicola, Gilliamella apicola Kwong and Moran 2013, NCIMB 14804, strain wkB1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHN26508.1	AHN26509.1	GAPWK_1935	GAPWK_1936	tssE.	tssJ.	0.987
AHN26508.1	AHN26510.1	GAPWK_1935	GAPWK_1937	tssE.	tssG.	0.994
AHN26508.1	AHN26511.1	GAPWK_1935	GAPWK_1938	tssE.	tssF.	0.985
AHN26508.1	AHN26512.1	GAPWK_1935	GAPWK_1939	tssE.	tssA.	0.948
AHN26508.1	AHN26513.1	GAPWK_1935	GAPWK_1940	tssE.	tssM.	0.923
AHN26508.1	AHN26515.1	GAPWK_1935	GAPWK_1942	tssE.	Hypothetical protein.	0.865
AHN26508.1	AHN26519.1	GAPWK_1935	GAPWK_1946	tssE.	Putative membrane protein.	0.919
AHN26508.1	AHN26520.1	GAPWK_1935	GAPWK_1947	tssE.	tssK.	0.937
AHN26508.1	AHN26521.1	GAPWK_1935	GAPWK_1948	tssE.	tssC.	0.913
AHN26508.1	AHN26522.1	GAPWK_1935	GAPWK_1949	tssE.	tssB.	0.936
AHN26509.1	AHN26508.1	GAPWK_1936	GAPWK_1935	tssJ.	tssE.	0.987
AHN26509.1	AHN26510.1	GAPWK_1936	GAPWK_1937	tssJ.	tssG.	0.984
AHN26509.1	AHN26511.1	GAPWK_1936	GAPWK_1938	tssJ.	tssF.	0.972
AHN26509.1	AHN26512.1	GAPWK_1936	GAPWK_1939	tssJ.	tssA.	0.938
AHN26509.1	AHN26513.1	GAPWK_1936	GAPWK_1940	tssJ.	tssM.	0.937
AHN26509.1	AHN26515.1	GAPWK_1936	GAPWK_1942	tssJ.	Hypothetical protein.	0.891
AHN26509.1	AHN26519.1	GAPWK_1936	GAPWK_1946	tssJ.	Putative membrane protein.	0.939
AHN26509.1	AHN26520.1	GAPWK_1936	GAPWK_1947	tssJ.	tssK.	0.901
AHN26509.1	AHN26521.1	GAPWK_1936	GAPWK_1948	tssJ.	tssC.	0.913
AHN26509.1	AHN26522.1	GAPWK_1936	GAPWK_1949	tssJ.	tssB.	0.938

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.945

expected number of edges:

15

PPI enrichment p-value:

4.85e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006096

Glycolytic process

8 of 24

2.48

7.01

2.75e-15

GO:0019318

Hexose metabolic process

8 of 48

2.17

5.81

3.36e-14

GO:0006006

Glucose metabolic process

5 of 23

2.29

4.02

6.22e-09

GO:0006091

Generation of precursor metabolites and energy

9 of 162

1.7

3.73

1.20e-12

GO:0051156

Glucose 6-phosphate metabolic process

4 of 15

2.38

3.34

3.10e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004332

Fructose-bisphosphate aldolase activity

4 of 4

2.95

3.84

8.88e-08

GO:0008865

Fructokinase activity

3 of 7

2.58

2.27

6.25e-05

GO:0005536

Glucose binding

3 of 7

2.58

2.27

6.25e-05

GO:0004340

Glucokinase activity

3 of 7

2.58

2.27

6.25e-05

GO:0030246

Carbohydrate binding

4 of 63

1.76

1.77

0.00013

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

10 of 835

1.03

1.23

1.70e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9210

Glycolysis, and Pentose phosphate pathway

9 of 67

2.08

5.73

5.58e-15

CL:9224

Glycolytic process

5 of 14

2.51

4.37

3.02e-09

CL:9212

Glycolysis, and Pentose phosphate pathway

7 of 57

2.04

4.36

6.53e-11

CL:9241

Fructose-bisphosphate aldolase activity, and Triosephosphate isomerase

3 of 5

2.73

2.65

1.27e-05

CL:9331

Regulation of Glucokinase by Glucokinase Regulatory Protein, and Beta-mannosidase activity

2 of 5

2.55

1.27

0.0047

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00010

Glycolysis / Gluconeogenesis

7 of 82

1.88

3.84

1.83e-10

map00030

Pentose phosphate pathway

5 of 31

2.16

3.69

1.65e-08

map00051

Fructose and mannose metabolism

5 of 54

1.92

3.08

8.67e-08

map00052

Galactose metabolism

5 of 61

1.87

2.94

1.29e-07

map00520

Amino sugar and nucleotide sugar metabolism

6 of 119

1.66

2.65

6.02e-08

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-170822

Regulation of Glucokinase by Glucokinase Regulatory Protein

3 of 6

2.65

2.47

2.70e-05

MAP-70171

Glycolysis

4 of 27

2.12

2.45

1.21e-05

MAP-71387

Metabolism of carbohydrates

7 of 245

1.41

1.85

1.84e-06

MAP-70370

Galactose catabolism

2 of 7

2.41

1.19

0.0063

MAP-70326

Glucose metabolism

4 of 127

1.45

1.14

0.0021

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

5 of 15

2.48

4.42

2.16e-09

KW-0119

Carbohydrate metabolism

2 of 24

1.87

0.72

0.0430

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01116

Fructose-bisphosphate aldolase class-II

2 of 2

2.95

1.2

0.0068

PF03727

Hexokinase

2 of 6

2.48

0.98

0.0159

PF00349

Hexokinase

2 of 6

2.48

0.98

0.0159

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000771

Fructose-bisphosphate aldolase, class-II

2 of 2

2.95

0.95

0.0193

IPR022673

Hexokinase, C-terminal

2 of 6

2.48

0.74

0.0450

IPR022672

Hexokinase, N-terminal

2 of 6

2.48

0.74

0.0450

IPR001312

Hexokinase

2 of 6

2.48

0.74

0.0450

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