AHN26779.1 protein (Gilliamella apicola) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AHN26779.1

D-mannonate oxidoreductase. (489 aa)

Predicted Functional Partners:

uxaC

0.978

uxuA

0.973

AHN25170.1

0.954

AHN25117.1

0.931

uxaC-2

0.918

AHN25118.1

0.904

AHN25120.1

0.902

AHN27293.1

0.646

AHN25014.1

0.555

AHN26777.1

0.540

Your Current Organism:

Gilliamella apicola

NCBI taxonomy Id: 1196095
Other names: ATCC BAA-2448, Candidatus Gilliamella apicola, G. apicola, Gilliamella apicola Kwong and Moran 2013, NCIMB 14804, strain wkB1

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHN25014.1	AHN25120.1	GAPWK_0437	GAPWK_0543	Fructose-specific phosphocarrier protein HPr / PTS system, fructose-specific IIA component.	D-mannonate oxidoreductase; Belongs to the mannitol dehydrogenase family.	0.555
AHN25014.1	AHN25170.1	GAPWK_0437	GAPWK_0593	Fructose-specific phosphocarrier protein HPr / PTS system, fructose-specific IIA component.	PTS system, mannitol-specific IIB component / PTS system, mannitol-specific IIC component.	0.956
AHN25014.1	AHN26779.1	GAPWK_0437	GAPWK_2206	Fructose-specific phosphocarrier protein HPr / PTS system, fructose-specific IIA component.	D-mannonate oxidoreductase.	0.555
AHN25014.1	AHN27293.1	GAPWK_0437	GAPWK_2720	Fructose-specific phosphocarrier protein HPr / PTS system, fructose-specific IIA component.	Hypothetical protein.	0.638
AHN25117.1	AHN25118.1	GAPWK_0540	GAPWK_0541	Starvation sensing protein RspA.	Starvation sensing protein RspB.	0.756
AHN25117.1	AHN25120.1	GAPWK_0540	GAPWK_0543	Starvation sensing protein RspA.	D-mannonate oxidoreductase; Belongs to the mannitol dehydrogenase family.	0.972
AHN25117.1	AHN26779.1	GAPWK_0540	GAPWK_2206	Starvation sensing protein RspA.	D-mannonate oxidoreductase.	0.931
AHN25117.1	uxuA	GAPWK_0540	GAPWK_2208	Starvation sensing protein RspA.	Mannonate dehydratase; Catalyzes the dehydration of D-mannonate.	0.914
AHN25118.1	AHN25117.1	GAPWK_0541	GAPWK_0540	Starvation sensing protein RspB.	Starvation sensing protein RspA.	0.756
AHN25118.1	AHN25120.1	GAPWK_0541	GAPWK_0543	Starvation sensing protein RspB.	D-mannonate oxidoreductase; Belongs to the mannitol dehydrogenase family.	0.963
AHN25118.1	AHN26779.1	GAPWK_0541	GAPWK_2206	Starvation sensing protein RspB.	D-mannonate oxidoreductase.	0.904
AHN25118.1	uxaC	GAPWK_0541	GAPWK_2205	Starvation sensing protein RspB.	Uronate isomerase.	0.902
AHN25118.1	uxaC-2	GAPWK_0541	GAPWK_2260	Starvation sensing protein RspB.	Uronate isomerase.	0.902
AHN25120.1	AHN25014.1	GAPWK_0543	GAPWK_0437	D-mannonate oxidoreductase; Belongs to the mannitol dehydrogenase family.	Fructose-specific phosphocarrier protein HPr / PTS system, fructose-specific IIA component.	0.555
AHN25120.1	AHN25117.1	GAPWK_0543	GAPWK_0540	D-mannonate oxidoreductase; Belongs to the mannitol dehydrogenase family.	Starvation sensing protein RspA.	0.972
AHN25120.1	AHN25118.1	GAPWK_0543	GAPWK_0541	D-mannonate oxidoreductase; Belongs to the mannitol dehydrogenase family.	Starvation sensing protein RspB.	0.963
AHN25120.1	AHN25170.1	GAPWK_0543	GAPWK_0593	D-mannonate oxidoreductase; Belongs to the mannitol dehydrogenase family.	PTS system, mannitol-specific IIB component / PTS system, mannitol-specific IIC component.	0.954
AHN25120.1	AHN26779.1	GAPWK_0543	GAPWK_2206	D-mannonate oxidoreductase; Belongs to the mannitol dehydrogenase family.	D-mannonate oxidoreductase.	0.902
AHN25120.1	AHN27293.1	GAPWK_0543	GAPWK_2720	D-mannonate oxidoreductase; Belongs to the mannitol dehydrogenase family.	Hypothetical protein.	0.646
AHN25120.1	uxaC	GAPWK_0543	GAPWK_2205	D-mannonate oxidoreductase; Belongs to the mannitol dehydrogenase family.	Uronate isomerase.	0.918

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.869

expected number of edges:

15

PPI enrichment p-value:

8.68e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000105

Histidine biosynthetic process

8 of 10

2.07

4.78

5.23e-12

GO:0006520

Cellular amino acid metabolic process

9 of 106

1.09

1.32

3.87e-07

GO:0044281

Small molecule metabolic process

11 of 248

0.81

0.84

3.87e-07

GO:1901566

Organonitrogen compound biosynthetic process

9 of 288

0.66

0.54

0.00050

GO:0044249

Cellular biosynthetic process

10 of 373

0.59

0.5

0.00031

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000107

Imidazoleglycerol-phosphate synthase activity

2 of 2

2.16

0.74

0.0427

GO:0016763

Pentosyltransferase activity

3 of 16

1.43

0.66

0.0427

GO:0003824

Catalytic activity

11 of 692

0.36

0.26

0.0418

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 505

0.5

0.42

0.00037

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1375

Histidine metabolism

9 of 11

2.07

5.58

1.60e-14

CL:1379

Histidine biosynthesis

5 of 5

2.16

3.4

8.75e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00340

Histidine metabolism

8 of 12

1.99

4.7

1.66e-12

map01230

Biosynthesis of amino acids

9 of 102

1.11

1.42

5.67e-08

map01110

Biosynthesis of secondary metabolites

10 of 191

0.88

0.96

2.22e-07

map01100

Metabolic pathways

10 of 484

0.48

0.39

0.0012

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0368

Histidine biosynthesis

7 of 8

2.1

4.55

4.83e-11

KW-0456

Lyase

4 of 26

1.35

1.17

0.00094

KW-0963

Cytoplasm

7 of 89

1.06

1.11

2.49e-05

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (20%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About