STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ligADNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (662 aa)    
Predicted Functional Partners:
leuS
COG0495 Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
 
 0.955
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.845
asnC
COG0017 Aspartyl/asparaginyl-tRNA synthetases; Belongs to the class-II aminoacyl-tRNA synthetase family.
       0.836
WEN_02850
DNA helicase, UvrD type; COG0210 Superfamily I DNA and RNA helicases.
  
  
 0.765
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.693
alaS
COG0013 Alanyl-tRNA synthetase.
  
    0.688
WEN_02865
Trifunctional protein ribF/mnmA; COG0482 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain.
       0.672
WEN_00685
DNA polymerase I; COG0258 5'-3' exonuclease (including N-terminal domain of PolI).
     
 0.666
WEN_00690
COG0587 DNA polymerase III, alpha subunit.
     
 0.565
gatA
COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases; Belongs to the amidase family.
  
    0.534
Your Current Organism:
Mycoplasma wenyonii
NCBI taxonomy Id: 1197325
Other names: M. wenyonii str. Massachusetts, Mycoplasma wenyonii str. Massachusetts, Mycoplasma wenyonii strain Massachusetts
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