NEOLI_002816 protein (Neolecta irregularis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

NEOLI_002816

GTPase-activating protein gyp1. (398 aa)

Predicted Functional Partners:

NEOLI_004194

0.859

NEOLI_004252

0.792

NEOLI_003335

0.734

NEOLI_002056

0.691

NEOLI_004566

0.690

NEOLI_001688

0.681

NEOLI_003905

0.681

NEOLI_000570

0.681

NEOLI_003653

0.681

NEOLI_002146

0.681

Your Current Organism:

Neolecta irregularis

NCBI taxonomy Id: 1198029
Other names: N. irregularis DAH-3, Neolecta irregularis DAH-3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NEOLI_000570	NEOLI_001688	A0A1U7LKF9	A0A1U7LGR9	54S ribosomal protein L51, mitochondrial.	54S ribosomal protein L4, mitochondrial.	0.962
NEOLI_000570	NEOLI_002056	A0A1U7LKF9	A0A1U7LPM9	54S ribosomal protein L51, mitochondrial.	54S ribosomal protein L27, mitochondrial.	0.976
NEOLI_000570	NEOLI_002146	A0A1U7LKF9	A0A1U7LS50	54S ribosomal protein L51, mitochondrial.	DNA polymerase delta subunit 3.	0.964
NEOLI_000570	NEOLI_002816	A0A1U7LKF9	A0A1U7LHG9	54S ribosomal protein L51, mitochondrial.	GTPase-activating protein gyp1.	0.681
NEOLI_000570	NEOLI_003335	A0A1U7LKF9	A0A1U7LH02	54S ribosomal protein L51, mitochondrial.	37S ribosomal protein S24, mitochondrial.	0.962
NEOLI_000570	NEOLI_003653	A0A1U7LKF9	A0A1U7LNH5	54S ribosomal protein L51, mitochondrial.	54S ribosomal protein L17, mitochondrial.	0.981
NEOLI_000570	NEOLI_003905	A0A1U7LKF9	A0A1U7LH63	54S ribosomal protein L51, mitochondrial.	Mitochondrial 37S ribosomal protein S27.	0.924
NEOLI_000570	NEOLI_004194	A0A1U7LKF9	A0A1U7LV05	54S ribosomal protein L51, mitochondrial.	37S ribosomal protein MRP17, mitochondrial.	0.963
NEOLI_000570	NEOLI_004566	A0A1U7LKF9	A0A1U7LS94	54S ribosomal protein L51, mitochondrial.	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	0.975
NEOLI_001688	NEOLI_000570	A0A1U7LGR9	A0A1U7LKF9	54S ribosomal protein L4, mitochondrial.	54S ribosomal protein L51, mitochondrial.	0.962
NEOLI_001688	NEOLI_002056	A0A1U7LGR9	A0A1U7LPM9	54S ribosomal protein L4, mitochondrial.	54S ribosomal protein L27, mitochondrial.	0.976
NEOLI_001688	NEOLI_002146	A0A1U7LGR9	A0A1U7LS50	54S ribosomal protein L4, mitochondrial.	DNA polymerase delta subunit 3.	0.985
NEOLI_001688	NEOLI_002816	A0A1U7LGR9	A0A1U7LHG9	54S ribosomal protein L4, mitochondrial.	GTPase-activating protein gyp1.	0.681
NEOLI_001688	NEOLI_003335	A0A1U7LGR9	A0A1U7LH02	54S ribosomal protein L4, mitochondrial.	37S ribosomal protein S24, mitochondrial.	0.974
NEOLI_001688	NEOLI_003653	A0A1U7LGR9	A0A1U7LNH5	54S ribosomal protein L4, mitochondrial.	54S ribosomal protein L17, mitochondrial.	0.977
NEOLI_001688	NEOLI_003905	A0A1U7LGR9	A0A1U7LH63	54S ribosomal protein L4, mitochondrial.	Mitochondrial 37S ribosomal protein S27.	0.919
NEOLI_001688	NEOLI_004194	A0A1U7LGR9	A0A1U7LV05	54S ribosomal protein L4, mitochondrial.	37S ribosomal protein MRP17, mitochondrial.	0.964
NEOLI_001688	NEOLI_004566	A0A1U7LGR9	A0A1U7LS94	54S ribosomal protein L4, mitochondrial.	Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.	0.966
NEOLI_002056	NEOLI_000570	A0A1U7LPM9	A0A1U7LKF9	54S ribosomal protein L27, mitochondrial.	54S ribosomal protein L51, mitochondrial.	0.976
NEOLI_002056	NEOLI_001688	A0A1U7LPM9	A0A1U7LGR9	54S ribosomal protein L27, mitochondrial.	54S ribosomal protein L4, mitochondrial.	0.976

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.868

expected number of edges:

11

PPI enrichment p-value:

0.000207

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009231

Riboflavin biosynthetic process

6 of 8

2.48

4.92

1.72e-10

GO:0018130

Heterocycle biosynthetic process

8 of 253

1.1

1.27

2.73e-06

GO:1901362

Organic cyclic compound biosynthetic process

8 of 268

1.08

1.21

3.82e-06

GO:0009156

Ribonucleoside monophosphate biosynthetic process

3 of 38

1.5

0.98

0.0071

GO:0044271

Cellular nitrogen compound biosynthetic process

8 of 353

0.96

2.89e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003935

GTP cyclohydrolase II activity

2 of 2

2.6

1.06

0.0117

GO:0016814

Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

3 of 17

1.85

1.04

0.0092

GO:0016765

Transferase activity, transferring alkyl or aryl (other than methyl) groups

3 of 24

1.7

0.96

0.0117

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

6 of 414

0.76

0.46

0.0271

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:998

Riboflavin biosynthesis

5 of 5

2.6

4.29

6.15e-09

CL:996

Mixed, incl. Pantothenate metabolic process, and Riboflavin metabolism

6 of 18

2.12

3.81

6.15e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

psul00740

Riboflavin metabolism

6 of 7

2.53

5.57

9.08e-12

psul01110

Biosynthesis of secondary metabolites

8 of 380

0.92

2.57e-05

psul00790

Folate biosynthesis

2 of 21

1.58

0.71

0.0363

psul02024

Quorum sensing

3 of 88

1.13

0.6

0.0363

psul01100

Metabolic pathways

9 of 842

0.63

0.52

0.00053

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0686

Riboflavin biosynthesis

4 of 4

2.6

3.46

3.00e-07

KW-0630

Potassium

2 of 5

2.2

1.03

0.0121

KW-0862

Zinc

3 of 80

1.18

0.57

0.0488

KW-0479

Metal-binding

5 of 272

0.87

0.53

0.0219

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00925

GTP cyclohydrolase II

2 of 2

2.6

0.92

0.0210

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